Serum concentrations of antimicrobial peptide cathelicidin LL-37 in patients with bacterial lung infections

Central-European Journal of Immunology
Karol MajewskiEwa Brzezińska-Błaszczyk

Abstract

Nowadays, data indicate that antimicrobial peptides play an important role in immunological defense. Human cathelicidin LL-37 possesses a broad spectrum of antimicrobial properties against Gram-positive and Gram-negative bacteria, and is thereby an important component of defense mechanisms within the respiratory tract. In this study, we determined the LL-37 serum level in patients with pneumonia caused by different bacteria species in comparison with healthy subjects. Twenty-two patients with pneumonia caused by coccal Gram-positive bacteria (I), 16 patients with pneumonia caused by Haemophilus influenzae (II), 29 patients with pneumonia caused by members of the Enterobacteriaceae (III), 13 patients caused by non-fermenting Gram-negative bacteria (IV), and 30 healthy controls were enrolled in the study. Serum LL-37 concentration was measured using an enzyme-linked immunosorbent assay (ELISA). The mean LL-37 concentration in pneumonia patients was significantly higher in group I (p = 0.0032), group II (p = 0.0022), and group III (p = 0.019), and significantly lower in group IV (p = 0.000004) as compared with healthy volunteers. Our data suggest that LL-37 plays an important role in defense mechanisms during pneumonia. The reduce...Continue Reading

Citations

Jun 23, 2020·Journal of Peptide Science : an Official Publication of the European Peptide Society·Athanasios TzitzilisEugenia Panou-Pomonis
Aug 4, 2020·Journal of Translational Autoimmunity·Alejandro Moreno-AngaritaGabriel J Tobón
Jul 2, 2021·Frontiers in Cellular and Infection Microbiology·Antonio MorettaPatrizia Falabella

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Methods Mentioned

BETA
bronchoalveolar lavage
ELISA

Software Mentioned

Statistica

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