Serum concentrations of CCR4 ligands in relation to clinical severity of atopic dermatitis in Egyptian children

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Gehan Ahmed MostafaIbrahim El-Sayed El-Far

Abstract

T helper 2 (Th2) lymphocytes, the key effector cells in pathogenesis of atopic dermatitis (AD), express CCR4 receptors. CCR4 ligands (macrophage-derived chemokine 'MDC' and thymus and activation-regulated chemokine 'TARC') direct trafficking and recruitment of Th2 cells into lesional skin in AD. These chemokines appear to be useful inflammatory markers for assessing severity of AD in adults. However, the same results have not been replicated in children. Therefore, we were stimulated to elucidate the expression of CCR4 ligands in children with AD and their relation to clinical disease severity. To investigate this, serum concentrations of CCR4 ligands were determined in 60 children, of whom 30 had AD and 30 were healthy matched subjects. Patients were classified into mild (n = 8), moderate (n = 12) and severe (n = 10) according to the objective scoring AD (obj-SCORAD) index. Serum concentrations of MDC and TARC were significantly increased in children with AD (2697 +/- 982.6 pg/ml and 945.5 +/- 494.7 pg/ml, respectively) compared with controls (357.2 +/- 233.2 pg/ml and 214.2 +/- 116.6 pg/ml, respectively, p < 0.0001). Serum levels of both chemokines went hand in hand with disease severity as they were significantly higher in s...Continue Reading

References

Jan 1, 1996·Journal of Leukocyte Biology·P ProostJ Van Damme
Jun 1, 1996·The Journal of Experimental Medicine·H Kita, G J Gleich
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·B KunzA Taïeb
Dec 31, 1997·American Journal of Respiratory Cell and Molecular Biology·E M MinshallQ Hamid
Jun 29, 2000·Archives of Dermatology·C Charman, H Williams
Jan 12, 2002·The American Journal of Pathology·Eric J KunkelJames J Campbell
Jul 10, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Atsushi MoritaKenji Sugita
Mar 12, 2003·Journal of Leukocyte Biology·Vanessa PinhoMauro M Teixeira
Mar 21, 2003·Journal of Clinical Immunology·Hirokuni HirataTakeshi Fukuda
Jun 6, 2003·The Journal of Allergy and Clinical Immunology·Santa Jeremy OnoMasako Toda
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas W LukacsCory M Hogaboam
Aug 13, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ting Fan LeungIris H S Chan
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Rafeul Alam, William W Busse
Mar 3, 2004·The Journal of Clinical Investigation·Donald Y M LeungQutayba A Hamid
Oct 30, 2004·Current Opinion in Immunology·Cezmi A AkdisMübeccel Akdis
Apr 2, 2005·Nature Reviews. Molecular Cell Biology·Eleonora CandiGerry Melino
Feb 9, 2006·European Journal of Pharmacology·Joost J Smit, Nicholas W Lukacs
Oct 7, 2006·Current Opinion in Immunology·Mübeccel Akdis
Mar 21, 2007·Chemical Immunology and Allergy·Bernhard HomeyAntti Lauerma

❮ Previous
Next ❯

Citations

Feb 25, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Takao FujisawaKunihiko Tamaki
Oct 25, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Edyta MachuraAlicja Kasperska-Zajac
Dec 3, 2013·Journal of the American Academy of Dermatology·Lawrence F EichenfieldRobert Sidbury
Sep 10, 2014·Journal of the American Academy of Dermatology·Janneke LandheerHeike Röckmann
Mar 10, 2015·Allergy, Asthma & Immunology Research·Jungsoo LeeKwang Hoon Lee
Jul 3, 2020·Experimental Dermatology·Wang Kuk SonYoung Yoo
Aug 20, 2009·Current Opinion in Allergy and Clinical Immunology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

© 2022 Meta ULC. All rights reserved