Serum concentrations of chloroquine in a patient with a late recrudescence of Kenyan Plasmodium falciparum malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene
M FaehlmannP Hedman

Abstract

A Swedish tourist who had visited Kenya fell ill with Plasmodium falciparum malaria 11 days after returning home, in spite of taking pyrimethamine (50 mg weekly) as malaria prophylaxis. Chloroquine treatment (25 mg base/kg body-weight) giving serum concentrations of 0.30 mumol/l cleared the patent parasitaemia and the patient recovered. Recrudescence occurred, however, within 42 days. A second chloroquine course (30 mg base/kg) gave serum levels up to 1.28 mumol/l. The patient improved rapidly and remained healthy during 28 days without renewed parasitaemia. Further follow-up for 10 months was uneventful. We consider it urgent to assess chloroquine concentrations in serum in patients being treated for falciparum malaria in order to obtain data on fully effective levels. Ineffective serum levels should be ruled out in cases not responding to chloroquine, especially when chloroquine-resistance is suspected.

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Citations

Jan 1, 1984·European Journal of Clinical Pharmacology·M Frisk-HolmbergB Domeij-Nyberg
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·R EspositoP Crocchiolo
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·S L HoffmanI Wiady
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·G OrlandoR Esposito
Dec 21, 2000·Tropical Medicine & International Health : TM & IH·R ShrettaR W Snow
Dec 16, 1982·The New England Journal of Medicine·B G WenigerS M Friedman
Nov 21, 1981·British Medical Journal·H M Gilles
Sep 11, 1982·British Medical Journal·L J Bruce-Chwatt

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