Serum concentrations of cortisone and cortisol in premature infants

Metabolism: Clinical and Experimental
M FujitakaK Ueda

Abstract

To determine the relationship between biological active cortisol and its inert metabolite cortisone accurately in premature infants, serum cortisone and cortisol concentrations were measured by reversed-phase high-performance liquid chromatography (HPLC) in a group of 232 premature infants and in a control group of 127 children and 88 adults. In the control group, serum cortisone concentrations were greater than serum cortisol levels during the first 2 months after birth; cortisol levels were higher than cortisone levels after 2 months of age. However, in premature infants, serum cortisone concentrations were greater than serum cortisol levels even after the first 2 months, and total concentrations of cortisone and cortisol were equal to those in controls. Results were then analyzed according to the equivalent gestational age of premature infants. Cortisone was predominant in premature infants older than 32 weeks of equivalent gestational age, but cortisol was higher than cortisone from equivalent gestational age 24 to 31 weeks. These findings suggest that the ability of premature infants to secrete glucocorticoids resembled that of normal controls. Also, the fetal zone of the cortex, which is associated with a predominance of ...Continue Reading

References

Dec 1, 1989·The Journal of Clinical Endocrinology and Metabolism·M M LeeT Moshang
Jan 1, 1986·Archives of Disease in Childhood·S ThomasI A Hughes
Mar 1, 1987·The Journal of Endocrinology·A M WallaceN F Taylor
Nov 1, 1986·Acta paediatrica Scandinavica·A Siamopoulou-MavridouP Harsoulis
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Feb 1, 1965·The Journal of Clinical Endocrinology and Metabolism·D A HILLMAN, C J GIROUD

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Citations

Aug 24, 2002·Pediatric Research·Roel J BoltHenriette A Delemarre-van de Waal
Jan 7, 2005·Pediatric Research·Matthias HeckmannStefan A Wudy
Jul 9, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·R J BoltH A Delemarre-van de Waal
Apr 25, 2006·Seminars in Fetal & Neonatal Medicine·Ruth E GrunauJeroen W B Peters
Mar 19, 2014·The Journal of Pediatrics·Ronald I ClymanUNKNOWN Patent Ductus Arteriosus Ligation/Hypotension Trial Investigators

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