Serum Concentrations of IgG4 in the Spanish Adult Population: Relationship with Age, Gender, and Atopy

PloS One
Iago CarballoArturo Gonzalez-Quintela

Abstract

Serum IgG4 concentrations are commonly measured in clinical practice. The aim of this study was to investigate serum IgG4 concentrations in adults and their potential relationship with demographic, lifestyle, metabolic, and allergy-related factors. Serum IgG4 concentrations were measured with a commercial assay in 413 individuals (median age 55 years, 45% males) who were randomly selected from a general adult population. Median IgG4 concentration was 26.8 mg/dL. Five out of the 413 individuals (1.2%) exhibited IgG4 concentrations >135 mg/dL, and 17 out of 411 (4.1%) exhibited an IgG4/total IgG ratio >8%. Serum IgG4 concentrations were significantly higher in males than in females and decreased with age. After adjusting for age and sex, serum IgG4 concentrations were not significantly influenced by alcohol consumption, smoking or common metabolic abnormalities (obesity and the related metabolic syndrome). Serum IgG4 concentrations were not significantly correlated with serum concentrations of proinflammatory cytokines and inflammation markers. Serum IgG4 concentrations were significantly correlated with IgE concentrations. Serum IgG4 concentrations tended to be higher in atopics (individuals with IgE-mediated sensitization to ae...Continue Reading

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Citations

Jan 28, 2017·Scandinavian Journal of Immunology·I CarballoA Gonzalez-Quintela
Jan 9, 2018·The World Allergy Organization Journal·Sheriene Moussa Afify, Isabella Pali-Schöll
May 14, 2020·PloS One·Cornelia Doriene Westerlaken-van GinkelAnthony E J Dubois
Jun 4, 2021·Immunity, Inflammation and Disease·Kristina Fruerlund RasmussenKristian Assing

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Methods Mentioned

BETA
biopsy

Software Mentioned

package
GAMLSS
Stata
R
SPSS

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