PMID: 6402888Jan 1, 1983Paper

Serum concentrations of immunoglobulins and free light chains before and after vascular events in essential hypertension

Acta Medica Scandinavica
B O Kristensen, K Sølling

Abstract

Serum concentrations of immunoglobulins (Ig) and free light chains (LC) of Ig have been determined at regular intervals during five years in patients with essential hypertension and correlated to development of vascular complications. In 6 cardiac event patients serum IgG increased by 11.9% (p less than 0.05) and LC by 19.8% (p less than 0.05). IgG levels correlated positively with LC levels (r = 0.59, p less than 0.001) and changes in IgG correlated positively with changes in LC (r = 0.46, p less than 0.01). The post-event increments in IgG persisted up to 21 months. No significant changes in serum concentrations of IgA, IgM, albumin and creatinine were found. In 10 cerebral event patients and in matched groups of 15 uncomplicated hypertensive patients, no significant changes in the above parameters could be demonstrated. It is concluded that heart tissue damage in essential hypertension induces a long-lasting stimulation of B-lymphocytes, and it is suggested that the high Ig levels found in as yet uncomplicated hypertensive patients may reflect an ongoing damage of the vascular bed.

References

Jan 1, 1978·Acta Medica Scandinavica·B O Kristensen, P L Andersen
May 15, 1979·International Journal of Cancer. Journal International Du Cancer·M FersonP Hersey
Dec 14, 1974·Lancet·J D MathewsI R Mackay
Nov 18, 1967·Lancet·D M Weir
Apr 18, 1970·British Medical Journal·A Ebringer, A E Doyle
Mar 1, 1971·The American Journal of Medicine·A EbringerA E Doyle
May 27, 1961·Lancet·E N EhrenfeldA M Davies

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Citations

Jun 2, 2017·Physiological Reviews·Bernardo Rodriguez-IturbeRichard J Johnson
Nov 25, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Sailesh C Harwani

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