Serum concentrations of L-arginine and L-homoarginine in male patients with intermittent claudication: a cross-sectional and prospective investigation in the CAVASIC Study

Atherosclerosis
Lena VoglBarbara Kollerits

Abstract

High serum concentrations of l-arginine and l-homoarginine increase nitric oxide (NO) availability and thereby improve endothelial function. Information about the association of these markers with peripheral arterial disease (PAD) and related outcomes is sparse. l-arginine, its metabolites and l-homoarginine were analyzed in the CAVASIC Study including 232 male patients diagnosed with intermittent claudication and 246 age- and diabetes-matched controls. After the baseline investigation PAD patients were prospectively followed (median 7 years). The association of these markers with symptomatic PAD at baseline, incident cardiovascular events and all-cause mortality was assessed. At baseline each increase of ln-l-homoarginine and l-arginine by one standard deviation was associated with symptomatic PAD: OR=0.75, 95%CI 0.59-0.96, P=0.02 and OR=1.36, 95%CI 1.07-1.73, P=0.01, respectively (both models adjusted for ln-CRP, GFR, HDL cholesterol, and current smoking). Only l-arginine remained significant after additional adjustment for ln-NT-proBNP and hs-cTnT: OR=1.49, P=0.002. In the Cox regression analysis elevated ln-l-homoarginine significantly reduced the risk to die (n=38) even independent from ln-NT-proBNP and hs-cTnT: HR=0.59, 9...Continue Reading

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Citations

May 2, 2015·Amino Acids·Stefan PilzAndreas Tomaschitz
May 29, 2018·European Journal of Clinical Investigation·Angelo ZinelluArduino A Mangoni
Mar 15, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Ekaterina S KaretnikovaRoman N Rodionov
Sep 26, 2019·Physiological Reports·Michael D WetzelAlaa S Awad
Mar 14, 2021·Physiological Reports·Michael D WetzelAlaa S Awad

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