PMID: 6973423Mar 1, 1981Paper

Serum concentrations of metabolites of vitamin D in patients with chronic renal failure (CRF). Consequences for the treatment with 1-alpha-hydroxy-derivatives

Clinical Endocrinology
J R JuttmannJ C Birkenhäger

Abstract

In forty-two patients with chronic renal failure (CRF), serum concentrations of 25-hydroxy-cholecalciferol (25-OHCC), 24,25-dihydroxy-cholecalciferol (24,25-OH2CC) and 1,25-dihydroxy-cholecalciferol (1,25-OH2CC) were measured before and during intermittent haemodialysis (IHD) and in a few cases also after renal transplantation. 25-OHCC and 24,25-OH2CC were measured by means of a competitive protein binding assay after Sephadex LH20 chromatography and 1,25-OH2CC by means of a radioimmunoassay after Sephadex LH20 and high pressure liquid chromatography (HPLC). In our patients serum values for 25-OHCC and 24,25-OH2CC showed a seasonal fluctuation as in normal individuals. The concentrations in the serum of 24,25-OH2CC and 1,25-OH2CC showed a positive correlation with renal function. With regard to 24,25-OH2CC this correlation was only found for the 24,25-OH2CC:25-OHCC ratio which was used to eliminate the seasonal fluctuation. For both dihydroxylated metabolites subnormal concentrations were found when the creatinine clearance was 40-50 ml/min and lower. It appears that the decrease of the plasma level of these metabolites of Vitamin D precedes (or is concomitant with) the changes in the serum values of calcium (Ca), phosphorus (P...Continue Reading

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Citations

Oct 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E R YendtG Rosenberg
Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D H Birkenhäger-FrenkelJ C Birkenhäger
Nov 1, 1995·Calcified Tissue International·V T FajtovaM S LeBoff
Jan 1, 1990·International Archives of Occupational and Environmental Health·K NogawaY Yamada
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Nov 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H JüppnerJ Brodehl
Oct 4, 2005·The British Journal of Nutrition·Armin ZittermannReiner Koerfer
Jan 16, 2007·Current Opinion in Lipidology·Armin ZittermannReiner Koerfer
Apr 25, 1981·British Medical Journal·J R JuttmannJ C Birkenhäger
Jul 21, 1984·British Medical Journal·G R Catto, N Muirhead
Jul 1, 1983·Kidney International·A K CheungL J Deftos
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Jun 10, 2008·Molecular Aspects of Medicine·Armin Zittermann, Reiner Koerfer
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Mar 1, 1988·Kidney International·R L PrinceR W Retallack

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