Serum concentrations of p, p'-DDE, HCB, PCBs and reproductive hormones among men of reproductive age.

Reproductive Toxicology
Kelly K FergusonJohn D Meeker

Abstract

Exposure to polychlorinated biphenyls (PCBs) has been associated with changes in reproductive hormone levels, however most groups studied have been highly exposed. We investigated the association of PCBs, hexachlorobenzene (HCB) and p, p'-DDE with serum sex hormones in 341 adult men from a US infertility clinic with exposure levels consistent with those observed in the general population. In crude regression models we observed several negative associations of PCBs and HCB with steroid hormone-binding globulin (SHBG) and total and free testosterone. After adjustment for lipids, age and BMI, nearly all significant associations were attenuated. A negative relationship remained between PCB 118 and SHBG (p<0.01), and relationships of dioxin-like PCBs with SHBG and total testosterone, and between PCB 118 and total testosterone, were suggestive. These results suggest a minimal relationship between PCB exposures at low background levels similar to those observed in the general population of the US and circulating reproductive hormones.

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Citations

Aug 27, 2013·International Journal of Hygiene and Environmental Health·Carmen FreireSergio Koifman
Jul 27, 2015·Reproductive Toxicology·Ina Olmer SpechtWendie A Robbins
Mar 15, 2015·Environmental Research·M S PetersenN Jørgensen
Jan 9, 2014·Environmental Health Perspectives·Lawrence M SchellUNKNOWN Akwesasne Task Force on the Environment
Dec 6, 2020·International Journal of Molecular Sciences·Elizabeth C Plunk, Sean M Richards
Feb 18, 2018·The Science of the Total Environment·Hoang Van LuongHisao Nishijo

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