Serum concentrations of pesticides including organophosphates, pyrethroids and neonicotinoids in a population with osteoarthritis in Saudi Arabia

The Science of the Total Environment
Adela Jing LiKurunthachalam Kannan

Abstract

Human exposure to pesticides is widespread and has received much attention in recent years because of its link to adverse health outcomes. Measurement of urinary concentrations of pesticides and their metabolites is often used in the assessment of body burdens of these chemicals. However, pesticides and their metabolites can be present in blood circulatory system, although little is known on serum levels of pesticides. In this study, we aimed to examine the occurrence and profile of four organophosphate (OP), five pyrethroid (PYR) insecticides, two phenoxy acid (PA) herbicides, 14 neonicotinoid (neonic) insecticides and six dialkylphosphate metabolites in serum from 25 individuals diagnosed with osteoarthritis in Jeddah, Saudi Arabia. 2-Isopropyl-4-methyl-6-hydroxypyrimidine (IMPY), 3,5,6-trichloro-2-pyridinol (TCPY), 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, 3-phenoxybenzoic acid, N-desmethyl acetamiprid, dimethylphosphate (DMP) and dimethylthiophosphate (DMTP) were detected in ≥80% of the serum samples analyzed. Metabolites of OPs, DMTP (median concentration: 2.14 ng/mL), DMP (1.04 ng/mL) and TCPY (0.84 ng/mL), collectively accounted for 67-83% of the total serum pesticide concentrations. Serum concen...Continue Reading

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Citations

Apr 12, 2021·Environmental Pollution·Hongxiu LiuAkhgar Ghassabian
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucía Vera-HerreraYolanda Picó
Jul 26, 2021·Colloids and Surfaces. B, Biointerfaces·Lumin YangFeng Zhou
Oct 26, 2021·Journal of Agricultural and Food Chemistry·Lianshan LiHongjie Wang

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