Serum concentrations of the axonal injury marker neurofilament light protein are not influenced by blood-brain barrier permeability

Brain Research
Marie KalmHenrik Zetterberg

Abstract

A blood biomarker to monitor individual susceptibility to neuronal injury from cranial radiotherapy could potentially help to individualize radiation treatment and thereby reduce the incidence and severity of late effects. An important feature of such a blood biomarker is that its concentration is not confounded by varying degrees of release from the brain into the blood across the blood-brain barrier (BBB). In this study, we investigated serum neurofilament light protein (NFL) concentrations in 21-day old mice following a single dose of cranial irradiation (8Gy). Cranial irradiation resulted in acute cell injury measured as a 12.9-fold increase in caspase activity 6h after irradiation; activation of inflammation measured by levels of CCL2 and increased BBB permeability measured by 14C-sucrose concentration ratios in brain and cerebrospinal fluid (CSF). Serum levels of NFL peaked at 6h after both anesthesia and cranial irradiation, but no timely correlation of serum NFL concentration with BBB permeability was found. Further, three groups of patients with different degrees of BBB impairment (measured as the CSF/serum albumin ratio) were investigated. There was no correlation between serum NFL concentration and CSF/serum albumin ...Continue Reading

References

Aug 1, 1989·The British Journal of Radiology·J F Fowler

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Citations

Oct 16, 2018·Current Opinion in Neurology·David J Simon, Trent A Watkins
Nov 9, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Katie E OsbornAngela L Jefferson
Feb 6, 2020·Neurology. Neuroimmunology and Neuroinflammation·Sinah EngelFelix Luessi
Jul 10, 2020·Neurology·Pashtun ShahimLeighton Chan
Dec 14, 2018·Frontiers in Neurology·Antoinette DepoorterSven Wellmann
Nov 5, 2020·Annals of Clinical and Translational Neurology·Christian BarroHoward L Weiner
Nov 26, 2020·Biomedicines·Simon ThebaultMark S Freedman
Feb 19, 2020·Journal of Equine Veterinary Science·Abubakar Musa MayakiAbdullah Rasedee
Sep 4, 2020·Annals of Neurology·Tamara G FongUNKNOWN SAGES Study Group
Mar 2, 2021·Neural Regeneration Research·Yuri Matteo FalzoneNilo Riva
Apr 13, 2021·Frontiers in Neuroscience·Simon ThebaultMark S Freedman

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