Serum concentrations of vitamins A and E in impaired glucose tolerance

Clinica Chimica Acta; International Journal of Clinical Chemistry
A TavridouK G Alberti

Abstract

Serum concentrations of vitamins A and E were measured in 32 subjects with impaired glucose tolerance (IGT) and 148 subjects with normal glucose tolerance using reversed-phase high-performance liquid chromatography. Fasting glucose, insulin and lipid concentrations were also measured. Serum vitamin A concentrations were higher in subjects with IGT 2.5 (1.1-3.4) vs. 2.1 (1.4-3.2) mumol/l [median (2.5-97.5 percentiles)] (P = 0.002), the difference remaining significant after adjustment for triglycerides (P = 0.028). There was a univariate association between vitamin A levels and insulin resistance (r = 0.164; P = 0.02) and in multivariate logistic regression analysis the relative risk of subjects with high vitamin A concentrations having IGT was 3.8 (P = 0.002). There were no differences in serum vitamin E concentrations between the groups. These data suggest that higher vitamin A concentrations found in non-insulin-dependent diabetes pre-date the onset of diabetes. Further studies are required to confirm this finding and to investigate the possibility of a role for vitamin A in the aetiology of diabetes and IGT.

References

Oct 1, 1992·Diabetes Research and Clinical Practice·V K MurthyD M Shipp
Jul 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·A CerielloP J Lefèbvre
May 1, 1991·The British Journal of Nutrition·C Bolton-SmithH Tunstall-Pedoe
Jan 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·A CollierM Small
Aug 1, 1990·American Journal of Epidemiology·B HerbethG Vernhès
Jun 30, 1989·Biochemical and Biophysical Research Communications·M D'AquinoR L Willson
Aug 1, 1989·The American Journal of Clinical Nutrition·T K BasuJ Leichter
Jan 1, 1988·Free Radical Biology & Medicine·L W Oberley
Jun 1, 1986·The Tohoku Journal of Experimental Medicine·Y WakoS Kimura
Jul 1, 1985·Annals of Clinical Biochemistry·J M Burrin, C P Price
Feb 1, 1985·Analytical Biochemistry·A G Lowe, A R Walmsley
Oct 1, 1967·Diabetes·W H Bowles
Nov 15, 1982·Biochemical Pharmacology·W J Malaisse
Nov 1, 1995·The American Journal of the Medical Sciences·H SasakiN Tada
Oct 1, 1994·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P E BealesP Pozzilli

❮ Previous
Next ❯

Citations

Jan 1, 2004·Environmental Health and Preventive Medicine·Kazuko HiraiMathura P Shrestha
Nov 5, 2015·Diabetes Management·Steven E Trasino, Lorraine J Gudas
Jun 28, 2012·Diabetes & Metabolism Journal·Eun-Jung Rhee, Jorge Plutzky
Mar 29, 2014·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Márcia TeskeRoseli Oselka S Sarni
Sep 13, 2005·The American Journal of Clinical Nutrition·Terry CoyneJonathan Shaw
Nov 25, 2020·Journal of Medicinal Food·Yan ZhangGuoxun Chen
Mar 9, 2021·Frontiers in Endocrinology·Yunting ZhouJianhua Ma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved