Serum Copper and Zinc Levels Among Iranian Colorectal Cancer Patients

Biological Trace Element Research
Zahra KhoshdelMahyar Malekzadeh

Abstract

Alterations of trace element concentrations adversely affect biological processes and could promote carcinogenesis. Only a few studies have investigated the degree of changes in copper and zinc levels in colorectal cancer (CRC). The aim of the present study was to compare the serum copper (Cu) and zinc (Zn) concentrations in patients with CRC from Iran with those of healthy subjects. Cu and Zn concentrations in the serum of 119 cancer patients and 128 healthy individuals were measured by atomic absorption spectrometry. We found a significant decrease in the total mean serum Cu and Zn concentrations in CRC patients as compared with the control group (137.5 ± 122.38 vs. 160.68 ± 45.12 μg/dl and 81.04 ± 52.05 vs. 141.64 ± 51.75, respectively). However, the serum Cu/Zn ratio in the patient group was significantly higher than that measured in the control group (p = 0.00). There was no significant difference in the mean values of serum Cu and Zn concentrations between young (<60 years) and elderly (≥60 years) patients. However, the Cu/Zn ratio in <60-year cases was significantly higher than that in ≥60-year age group (p < 0.05). In addition, mean serum Cu level in normal weight patients was significantly higher than that in overweigh...Continue Reading

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Citations

Jun 3, 2016·Middle East Journal of Digestive Diseases·Shirin MoossaviAshraf Mohamadkhani
Oct 5, 2016·Middle East Journal of Digestive Diseases·Kamran B Lankarani
Sep 25, 2019·Nutrients·Dorota Skrajnowska, Barbara Bobrowska-Korczak
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