Serum Copper is not Altered in Frontotemporal Lobar Degeneration

Journal of Alzheimer's Disease : JAD
Rosanna SquittiRoberta Ghidoni

Abstract

Meta-analyses show copper dyshomeostasis in Alzheimer's disease. However, a study evaluating copper changes in other neurodegenerative forms of dementia has not yet been performed. In this study, we assessed copper, ceruloplasmin, copper not bound to ceruloplasmin, and copper to ceruloplasmin ratio in 85 patients affected by frontotemporal lobar degeneration (FTLD) and 55 healthy controls. Data were analyzed through multivariate ANOVA models taking into account age and sex as covariates and the stratification for FTLD variants, after calculating power analysis to ensure the reliability of the conclusions drawn. The study revealed no difference between the groups.

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Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Mariacristina SiottoRosanna Squitti
Jan 12, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Rosanna SquittiNicola A Colabufo
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Nov 28, 2017·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Rosanna SquittiMariacristina Siotto

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Citations

Jun 18, 2020·Biomolecules·Fábio C CoelhoAnna-Camilla Moonen
Nov 14, 2020·Journal of Alzheimer's Disease : JAD·Anastasia De LucaRosanna Squitti

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