Serum cortisol binding capacity and cortisol concentration in the pregnant baboon and its fetus during gestation.

Endocrinology
R E Oakey

Abstract

The cortisol binding capacity of serum from 11 pregnant baboons (38 samples) and from 7 baboon fetuses delivered prematurely or at term was measured after removal of endogenous steroids. Values for maternal serum collected between 60 and 120 days after mating (59.0 +/- 6.4 mug/100 ml, mean +/- SD) were greater than those for serum collected at term (42.3 +/- 4.9 mug/100 ml). The cortisol-binding capacity of fetal serum collected between 100 and 132 days' gestation was similar to that of the corresponding maternal sample, but at term was only 50% of the maternal value. The rate of clearance of cortisol from both fetal and maternal serum may therefore increase progressively during the last trimester of pregnancy. This effect is likely to be more marked in the fetus. The cortisol binding capacity of 15 serum samples from 9 non-pregnant baboons was 33.4 +/- 5.5 mug/100 ml. Mestranol2 (administered 200 mug/day im for 15 days) significantly increased the serum cortisol binding capacity. The concentration of cortisol in maternal serum from 7 pregnant baboons (10 samples) was 44.0 +/- 8.4 mug/100 ml and was independent of the state of gestation. In fetal serum the cortisol concentration was 4 mug/100 ml before 168 days' gestation and r...Continue Reading

Citations

Feb 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·L A PerryR E Oakey
Jun 1, 1977·Journal of Steroid Biochemistry·H S SchillerP H Pétra
Dec 1, 1981·Journal of Steroid Biochemistry·W G GoodmanU Westphal
Feb 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·X F ZhaoG L Hammond
Dec 1, 1980·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N GoncharovT Todua
Nov 12, 2015·General and Comparative Endocrinology·Phoebe D Edwards, Rudy Boonstra
May 15, 1978·American Journal of Obstetrics and Gynecology·R B JaffeC C Lawrence
Jan 1, 1978·Archives of Andrology·J P KarrA A Sandberg
May 1, 1978·The American Journal of Physiology·H S SchillerG P Sackett
Nov 21, 2017·General and Comparative Endocrinology·Phoebe D Edwards, Rudy Boonstra

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