PMID: 16649427May 3, 2006Paper

Serum creatinine and creatinine clearance to estimate renal function in essential hypertension

Nefrología : publicación oficial de la Sociedad Española Nefrologia
N S JabaryJ Bustamante

Abstract

The shortcoming of serum creatinine (SCr) as an index of renal function is well known, patients can have significantly decreased glomerular filtration rates (GFR) with normal range SCr values, making the recognition of renal dysfunction more difficult. This study was designed to estimate renal function and the prevalence of renal dysfunction in essential hypertensive patients, comparing SCr and 4 formulas used to measure the creatinine clearance (CrCl) (the urinary CrCl formula, Cockcroft-Gault, MDRD and body surface formula) The study included 721 essential hypertensive patients, 319 men (44.2%), 402 women (55.8%), mean age 56.3 +/- 13.9 (53.7 +/- 14.4 vs 58.3 +/- 13.3). In all subjects SCr was measured and 24-h urine sample was collected to evaluate CrCl. Creatinine clereance was calculated by 4 formulas. Patients were grouped according to age (< 40, 41-65, 65-75 and > 76) and renal function was classified as normal when SCr < 1.4 in women and 1.5 mg/dl in men and CrCl (> 60 ml/m, respectively) within the above written formulas. SCr increases with age (1.01 +/- 0.36 vs 1.3 +/- 1.15) and CrCl decreases according to the 4 formulas (107.6; 92.8; 74.7 and 57.3 for the urinary SCr formula); (117.7; 87.7; 65.9 and 49.5 for the CC f...Continue Reading

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