Serum creatinine as marker of kidney function in South Asians: a study of reduced GFR in adults in Pakistan

Journal of the American Society of Nephrology : JASN
Tazeen H JafarAndrew S Levey

Abstract

Migrant populations of South Asian origin have a higher risk for chronic kidney disease than the native whites. Several formulas have been developed to estimate kidney function from serum creatinine concentration. However, none of these has been validated in the South Asian population, which generally has different muscle mass composition than whites. A population-based cross-sectional study was performed on 262 individuals who were aged > or = 40 yr in Karachi, Pakistan. Reduced GFR was defined as creatinine clearance (Ccr) measured in 24-h urine collection of <60 ml/min per 1.73 m2. Creatinine excretion was compared with age- and gender-matched white individuals by comparison of observed versus expected results on the basis of a formula using t test. The agreement among Cockcroft Gault (CG) Ccr and Modification of Diet in Renal Disease (MDRD) Study GFR equations was assessed by regression analyses, and the degree of accuracy of estimated versus measured GFR was determined. Mean (95% confidence interval) creatinine excretion was 1.7 (1.0 to 2.4) mg/kg per d lower than expected for age- and gender-matched white individuals (P < 0.001). The coefficient of determination for measured Ccr on the logarithmic scale was 66.7 and 55.6%...Continue Reading

References

Apr 21, 1979·British Medical Journal·F K JacobsenN S Heilskov
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Mar 1, 1987·Early Human Development·S W D'SouzaK I Cinkotai
Sep 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·M Walser
Feb 1, 1983·British Journal of Clinical Pharmacology·M MayersohnR Achari
Dec 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·A S SheraH King
Dec 1, 1995·Computer Methods and Programs in Biomedicine·F SchoonjansF H Comhaire
Sep 1, 2000·The American Journal of Clinical Nutrition·R C LeeS B Heymsfield
Oct 9, 2002·Statistics in Medicine·David Faraggi, Benjamin Reiser
Nov 8, 2002·The New England Journal of Medicine·Andrew S Levey
Jan 10, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·C M FischbacherK G M M Alberti
Apr 26, 2003·Journal of Hypertension·Tazeen H JafarNish Chaturvedi
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Wendy Weinstock BrownJohn M Flack
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Jul 17, 2003·Kidney International. Supplement·Vinay Sakhuja, Kamal Sud
Jul 26, 2003·QJM : Monthly Journal of the Association of Physicians·A TrehanR Gokal
Sep 13, 2003·Kidney International·Tazeen H JafarAndrew S Levey
Oct 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nicholas DreyMary Rogerson

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Citations

Mar 5, 2011·International Urology and Nephrology·Nomandla D MadalaIndiran P Naiker
Oct 3, 2007·Nature Clinical Practice. Nephrology·Nathaniel Berman, Thomas H Hostetter
Mar 10, 2006·The New England Journal of Medicine·Tazeen H Jafar
Feb 20, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tazeen H JafarShiraz Hashmi
Jan 27, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John B EastwoodFrancesco P Cappuccio
Mar 9, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jung Pyo LeeYon Su Kim
Mar 2, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kearkiat PraditpornsilpaSomchai Eiam-Ong
May 20, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Saleem JessaniTazeen H Jafar
Jun 22, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrew DavenportAndrew Kenneth Burroughs
Oct 6, 2005·Current Opinion in Nephrology and Hypertension·Paul E de Jong, Ron T Gansevoort
Apr 13, 2006·Current Opinion in Nephrology and Hypertension·Yoshio N Hall, Chi-Yuan Hsu
Apr 13, 2006·Current Opinion in Nephrology and Hypertension·Tazeen H Jafar
Apr 11, 2007·Current Opinion in Nephrology and Hypertension·Andrew D Rule
Apr 15, 2011·Current Opinion in Nephrology and Hypertension·Arsh Jain, Brenda R Hemmelgarn
Feb 3, 2009·BMC Public Health·Farhad HosseinpanahFereidoun Azizi
Sep 5, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Ariana Aguiar SoaresSandra Pinho Silveiro
Jan 18, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Sam W GaoKevin C Abbott
Jul 18, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Rajat TagoreSunil K Sethi
Oct 1, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Saleem JessaniTazeen H Jafar
Oct 17, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tazeen H Jafar, Sanjay Kumar Agarwal
May 16, 2012·Kidney International·Zeb I Saeed, Syed A Hussain
Aug 13, 2011·Kidney International·Nimmi T C AthuraliyaAlison L Jones
Nov 26, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joslyn ConleyUNKNOWN Alberta Kidney Disease Network
Mar 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A Stevens, Andrew S Levey
Nov 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Enyu ImaiSeiichi Matsuo
May 3, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jinn-Yuh GuhLea-Yea Chuang
Jan 20, 2007·Clinical Biochemistry·Stefan Herget-RosenthalWalter Hofmann
Mar 22, 2016·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Abdul Rauf HafeezSyed Fazal Akhtar
Mar 30, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M GeraF G Cosio
Dec 22, 2007·Seminars in Nuclear Medicine·Alain Prigent
Jul 30, 2014·Journal of Toxicology and Environmental Health. Part a·Erik M AndersenShoji F Nakayama
May 25, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John W StaniferUptal D Patel
Sep 6, 2008·American Journal of Hypertension·Saleem JessaniTazeen H Jafar

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