Serum creatinine is a poor marker of glomerular filtration rate in patients with spina bifida

Developmental Medicine and Child Neurology
A QuanM Baum

Abstract

Serum creatinine is used to estimate the glomerular filtration rate (GFR). The serum creatinine, however, may not accurately reflect the GFR in spina bifida patients, who often have decreased overall muscle mass resulting from spinal cord abnormalities. The relationship between the serum creatinine and GFR (obtained by [(125)I]iothalamate clearance) was examined in a population of spina bifida patients. Age-matched patients without spina bifida were used as controls. Results demonstrate that, for serum creatinines above 0.5 mg/dL, serum creatinine is a very poor predictor of GFR. Two patients with serum creatinines of 2.2 mg/dL are near end-stage renal disease with GFRs of 12.5 and 13 mL/minute per 1.73m2 and two patients were initiated on dialysis at the conclusion of the study. It is concluded that obtaining a GFR from a clearance study and not serum creatinine is the only reliable method to assess renal function in spina bifida patients once the serum creatinine is greater than 0.5 mg/dL.

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Citations

Nov 17, 2009·The Journal of Urology·Richard C AdamsWarren T Snodgrass
Oct 8, 2016·Environmental Health Perspectives·Ya-Ru YangChang-Chuan Chan
Jan 14, 2009·Scandinavian Journal of Urology and Nephrology·Kate AbrahamssonUlla Sillén
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Dec 9, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido Filler, Misan Lee
Apr 25, 2008·The Journal of Urology·K AbrahamssonU Sillén
Jun 13, 2020·Neurourology and Urodynamics·Ingrid EhrénÅke Seiger
Jul 14, 2000·Physiological Reviews·M Wyss, R Kaddurah-Daouk
Dec 1, 2020·Journal of Pediatric Rehabilitation Medicine·David B JosephHadley Wood

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