PMID: 11311223Apr 20, 2001Paper

Serum crosslaps in comparison to serum osteocalcin and urinary bone resorption markers

Clinical Biochemistry
P PeichlH Bröll

Abstract

In this study we evaluated the routine practice and clinical application of serum crosslaps to urinary-crosslaps, -N-telopeptide-related fraction of type 1 collagen, -deoxpyridinoline, -totalpyridinoline and serum osteocalcin. The utility of both the serum and urine immunoassays for bone formation and resorption marker were tested in a cohort of 593 female and male patients from our outpatient clinic for osteology and rheumatology and compared to important osteoporosis risk factors like age, gender, E2 deficiency, bone density and chronic renal failure. The biochemical maker of bone formation, serum osteocalcin exhibit significant correlations to all five tested serum and urinary markers of bone resorption (p < 0.0001) crosswise to all different groups of patients. The group of chronic renal failure patients showed no significant correlation between the tested bone turnover parameters and the serum creatinine level except a significant increase and correlation for serum crosslaps and for the ratio of serum and urinary crosslaps. Associations between the age of the patients and the markers of bone turnover were rather poor. We found a significant, negative association between serum and urinary bone turnover markers and bone dens...Continue Reading

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Citations

Jul 15, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M LateefA Azhar
Jul 11, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E LerchbaumW März
Mar 20, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John W McGehee, Roger B Johnson
Apr 10, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Hilkea RosenbrockPeter B Luppa
Apr 6, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Heinrich Schmidt-GaykHeinz Jürgen Roth
Oct 11, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Pauline M Camacho, Norma A Lopez
Jul 5, 2007·Journal of Periodontology·Akihiro YoshiharaHideo Miyazaki
Apr 22, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Markus HerrmannMarkus Seibel
Dec 1, 2015·Polish Journal of Veterinary Sciences·Z KiełbowiczC Pezowicz
Nov 28, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Giancarlo BilancioMassimo Cirillo
Apr 20, 2011·Journal of Periodontal Research·A YoshiharaH Miyazaki
Sep 21, 2002·Current Medical Research and Opinion·L M Pickering, J L Mansi
Jun 8, 2011·Australian Journal of Primary Health·Cheryl Kimber, Karen Grimmer-Somers

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