Serum Cystatin C as an Early Marker of Neutrophil Gelatinase-associated Lipocalin-positive Acute Kidney Injury Resulting from Cardiopulmonary Bypass in Infants with Congenital Heart Disease

Congenital Heart Disease
Carrie HerbertVinai Modem

Abstract

Acute kidney injury (AKI) is a common complication resulting from cardiopulmonary bypass in infants. Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a sensitive and specific marker of such injury. In this study, we compared the performance of serum cystatin C (Cys C) and serum creatinine (Cr) as early markers of renal dysfunction in infants undergoing cardiac surgery under bypass. The study was designed as a prospective observational study. The study was conducted in the cardiac intensive care unit (ICU) of a tertiary, academic children's hospital in the United States. Infants (age <1 year) undergoing cardiac surgery under cardiopulmonary bypass were included in the study. Acute kidney injury was defined based on postoperative urinary NGAL. A total of 17 infants were included in the study, and five of them developed AKI. Serum Cys C and Cr levels were measured postoperatively on days 1, 2, and 3, and compared with baseline levels. On postoperative day 2, infants with AKI showed significant change from baseline in serum Cys C levels compared with non-AKI infants (28% vs. -9%, P = .03). The two groups did not show significant differences with respect to rise in serum Cr on any of the 3 postoperative days. Serum Cr on...Continue Reading

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Citations

Jul 19, 2016·Progress in Pediatric Cardiology·John Lynn Jefferies, Prasad Devarajan
May 30, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Massimiliano CantinottiAldo Clerico
Jan 31, 2018·The Journal of Perinatal & Neonatal Nursing·Terri MarinJatinder Bhatia
May 27, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Candice Torres de Melo Bezerra CavalcanteAlexandre Braga Libório
Sep 25, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Slobodan GalićVedran Premužić

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