Serum cytokine levels related to exposure to volatile organic compounds and PM2.5 in dwellings and workplaces in French farmers - a mechanism to explain nonsmoking COPD

International Journal of Chronic Obstructive Pulmonary Disease
Christelle AudiIsabella Annesi-Maesano

Abstract

Although French farmers smoke less on average than individuals from the general population, they suffer more from COPD. Exposure to biological and chemical air pollutants in the farm may be the cause of these higher COPD rates. This study investigates the role of bio-contaminants, including the relationship of exposure to volatile organic compounds (VOCs) and fine particulate matter (of diameter of 2.5 µm [PM2.5]) objectively measured in the farm settings (dwellings and workplaces) to serum cytokines involved in COPD, in a sample of 72 farmers from 50 farms in the Auvergne region, France. Mean concentrations of VOCs were highest inside the home, while levels of PM2.5were highest in workplaces (stables and granaries). After adjusting for confounders, high exposure to PM2.5was significantly associated with a decreased level of serum cytokines (among others, IL13: β: -0.94, CI: -1.5 to -0.2,P-value =0.004; IL8: β: -0.82, CI: -1.4 to -0.2,P-value =0.005) and high exposure to VOCs according to a VOC global score with a decreased IL13 level (β: -0.5, CI: -0.9 to -0.1,P-value =0.01). Moreover, respiratory symptoms and diseases, including COPD, were associated with a decreased level of serum cytokines significantly in the case of IL5. ...Continue Reading

Citations

Oct 9, 2019·Multidisciplinary Respiratory Medicine·Cara Nichole MaesanoIsabella Annesi-Maesano
Sep 26, 2020·Frontiers in Public Health·Renata SistoPieranna Chiarella
Oct 12, 2018·Allergy, Asthma & Immunology Research·Dong Keon YonMan Yong Han
Dec 16, 2020·Environmental Pollution·Jahnavi SharmaPradyumna Kumar Mishra
Feb 17, 2021·Environmental Science and Pollution Research International·Faxue ZhangYunquan Zhang
May 1, 2021·International Journal of Environmental Research and Public Health·Kayan ClarkeEric S Coker

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