Serum cytokine levels related to multiple dimensions of fatigue in patients with primary Sjogren's syndrome

Annals of the Rheumatic Diseases
A HartkampR H W M Derksen

Abstract

To test whether serum levels of selected cytokines relate to different dimensions of fatigue in patients with primary Sjögren's syndrome (pSS). Sixty female patients with pSS filled out a questionnaire to assess multiple dimensions of fatigue. Scores were compared with values in a population based control group (n = 139). Levels of interleukin (IL)1beta, IL2, IL6, IL10, and tumour necrosis factor alpha were measured in serum with commercial sandwich ELISAs. The relationship between self reported dimensions of fatigue and these serum cytokine levels was determined. Patients with pSS had high scores at all dimensions of fatigue (p<0.001): general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue. Fatigue levels were not related to serum cytokine levels. The incidental finding that reduced motivation was higher in patients with detectable serum levels of IL10 (p = 0.04) disappeared after correction for multiple testing. Fatigue is prominent in patients with pSS and involves all dimensions of fatigue. The findings do not suggest a widespread effect of circulating cytokines on multiple aspects of fatigue.

Citations

Feb 12, 2010·Rheumatology·Wan-Fai Ng, Simon J Bowman
Oct 15, 2011·Arthritis Research & Therapy·Karstein HaldorsenJohan Gorgas Brun
Jan 5, 2011·Biological Research for Nursing·Debra LyonNancy L McCain
Jul 10, 2008·Scandinavian Journal of Rheumatology·H Forsblad d'EliaK Mannerkorpi
Jul 28, 2012·La Presse médicale·Simon Bowman, Francesca Barone
Jun 1, 2016·La Presse médicale·Jacques-Olivier Pers, Alain Saraux
Nov 5, 2019·Rheumatology·S Mechiel Korte, Rainer H Straub
Sep 1, 2015·Arthritis Care & Research·Theofanis KarageorgasClio P Mavragani
Mar 12, 2020·São Paulo Medical Journal = Revista Paulista De Medicina·Luciana Paula DardinVirginia Fernandes Moça Trevisani
Dec 30, 2016·Brain and Behavior·Belgin KoçerRümeysa Çetinkaya
Apr 18, 2019·Brain Sciences·Ciro ManzoJordi Serra-Mestres

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