SERUM CYTOKINE OF IL-2, IL-10 AND IL-12 LEVELS IN PATIENTS WITH STOMACH ADENOCARCINOMA

Arquivos De Gastroenterologia
Mohammad ShokrzadehYahya Saleh Tabari

Abstract

Gastric adenocarcinoma is the fourth most common cause of cancer-associated death worldwide. We evaluated the immunological status of patients with gastric cancer before surgery and circulating cytokines as potential diagnostic biomarkers for gastric cancer. We included 90 healthy controls and 95 patients with distal Gastric adenocarcinoma in Mazandaran, Sari, Iran. We measured serum IL-2, IL-10 and IL-12 Levels by a sandwich enzyme-linked immunosorbent assay using the IBL international GMBH kit. The serum IL-10 levels in the patients with Gastric adenocarcinoma were significantly higher than those of the healthy controls (P=0.02). There were no significant differences in serum IL-2 and IL-12 levels between patients with gastric cancer and healthy controls. Increased levels of IL-10 might be useful as diagnostic biomarkers for Gastric adenocarcinoma; however, this needs to be confirmed with larger number of patients and with control groups other than blood donors, properly age paired. These results suggest that positive expression of IL-10 may be useful as a molecular marker to distinguish stage of gastric cancers which can be more readily controlled.

References

Jun 18, 2002·Clinical & Experimental Metastasis·Claudio BrigatiRoberto Benelli
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jun 1, 2006·Cancer Science·Akihiko Yoshimura
May 4, 2007·The Journal of Clinical Investigation·Wan-Wan Lin, Michael Karin
Jan 11, 2013·Cancer·Chin HurEric J Feuer
Nov 12, 2013·Cancer Immunology, Immunotherapy : CII·Theresa L Whiteside
Mar 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Suzanne L TopalianF Stephen Hodi
May 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Xiong-Fei PanChun-Xia Yang
Sep 12, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lyuba D MitevaSpaska A Stanilova
Nov 30, 2014·Cancer Immunology, Immunotherapy : CII·Michelle N MessmerScott I Abrams
Dec 3, 2014·Trends in Cell Biology·Catharina HagerlingZena Werb
Dec 30, 2014·European Journal of Immunology·Huimin TaoAlfred E Chang
Jan 20, 2015·Current Opinion in Immunology·Sharad K Mittal, Paul A Roche
Feb 20, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ling ZhangSteven A Rosenberg
Mar 18, 2015·World Journal of Gastroenterology : WJG·Dipanjana Datta De, Susanta Roychoudhury
Apr 4, 2015·Science·Padmanee Sharma, James P Allison
Apr 10, 2015·Cancer Immunology Research·Kristen L DennisKhashayarsha Khazaie
May 9, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Austin H NguyenDevendra K Agrawal
Jul 15, 2015·The Journal of Clinical Investigation·Douglas Marvel, Dmitry I Gabrilovich
Nov 20, 2015·BioMed Research International·Ekaterina A Ivanova, Alexander N Orekhov
Nov 22, 2015·Advances in Biological Regulation·Marco Falasca, Riccardo Ferro
Mar 17, 2016·Cytokine & Growth Factor Reviews·Jens GeginatRichard A Flavell
Jul 11, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Nasrin Ghassemi-BarghiAbbas Jafarian Dehkordi
Aug 17, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aung NaingJeffrey R Infante

❮ Previous
Next ❯

Citations

Nov 14, 2019·Arquivos De Gastroenterologia·Mohammad ShokrzadehYahya Saleh Tabari
Jun 4, 2020·Arquivos De Gastroenterologia·Mohammad ShokrzadehAbolhasan Rezaei

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.