Abstract
Breast cancer is the leading cause of cancer-related death among women, with a more 20% 5-year survival rate after metastases. It is therefore critical to improve early diagnosis in order to improve disease prognosis. This study investigates cytokine profiles of breast cancer serum with the aim of identifying biomarkers for early diagnosis. A solid-phase antibody array was used for screening 274 biomarkers in serum from breast cancer patients. ELISA assay was carried out to identify biomarkers with differential expression. The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-β levels were lower. ELISA assay results confirmed those of the antibody array. Our results suggest that these cytokines, screened by antibody array, might serve as novel inflammatory markers in breast cancer patients. Whether these biomarkers are specific for breast cancer and can help to improve diagnoses and prognoses of breast cancer needs further investigation.
References
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Apr 3, 2003·Nature Reviews. Cancer·Ruth EtzioniLeland Hartwell
Sep 29, 2004·Molecular and Cellular Endocrinology·Véronique Maguer-Satta, Ruth Rimokh
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ina H BenoyLuc Y Dirix
Mar 25, 2005·Endocrine-related Cancer·Markus LusterFurio Pacini
Dec 3, 2005·Breast Cancer Research and Treatment·Carole MathelinMarie-Christine Rio
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Aug 3, 2007·Cancer Research·Diane RazanajaonaRuth Rimokh
Feb 28, 2008·Blood Cells, Molecules & Diseases·Nicholas M Burton, R Leo Brady
Mar 28, 2008·BMC Cancer·Julie DecockRobert Paridaens
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven W Cole
Sep 11, 2009·BMC Cancer·Enrrico BloiseFernando M Reis
Feb 24, 2011·Ultrasound Quarterly·Regina J HooleyLeslie M Scoutt
May 31, 2011·Frontiers in Bioscience (Landmark Edition)·Mingli LvZhongwei Lv
Mar 1, 2012·Gynecologic Oncology·Yi-Chen LeeShyng-Shiou F Yuan
Sep 17, 2013·The Journal of Biological Chemistry·Yamato KikkawaJeffrey H Miner
Oct 1, 2014·PloS One·Jayashri MahalingamYung-Chang Lin
Apr 4, 2015·Disease Markers·Adel M A AssiriMohamed F R Hassanien
Citations
Sep 10, 2016·PloS One·Juho JalkanenHarri Hakovirta
Aug 6, 2017·Biological Chemistry·Zhaohui TangRuoting Tang
Jul 18, 2017·Oncology Reports·Gemma A BarronGiovanna Bermano
Sep 14, 2019·International Journal of Molecular Sciences·Krista JuurikkaPirjo Åström
Jan 20, 2019·International Journal of Molecular Sciences·Raffaella MarconiLidia Strigari
Oct 31, 2020·Molecular Oncology·Wen-Fei WeiWei Wang
Nov 12, 2020·Molecular Oncology·Thilde TerkelsenIrina Gromova
Apr 4, 2020·Methods : a Companion to Methods in Enzymology·Mahmoud ElsabahyKenneth Oh
Jan 22, 2021·Journal of Oral Biosciences·Lyudmila V Bel'skayaVictor K Kosenok
Nov 6, 2020·Cancer Letters·Yen-Yun WangShyng-Shiou F Yuan