Serum cytokine profiles are altered in patients with progressive infantile hemangioma

Bioscience Trends
Tomoka YamashitaHironobu Ihn

Abstract

Infantile hemangioma sometimes grows rapidly to a significant size around the first 2 months of life, which can be problematic and even destroy normal tissue. However, it is very difficult to predict the tumor growth at the first visit and to decide necessity of treatment. Therefore the identification of the biomarkers that can indicate a tendency to grow is clinically very important. In the present study, we evaluated the possibility that serum cytokine levels are available as the marker of hemangioma growth. Progressive hemangioma was defined as a lesion showing increased tumor size and/or coloration two weeks before and after the serum sampling, and we used membrane array to compare the twenty cytokine profiles between the sera of 3 progressive hemangioma patients and sex-/age-matched non-progressive hemangioma patients. As a result, many of the 20 cytokines were detected in the patients' sera. When a 2-fold difference in the mean levels of each group was considered meaningful, 6 of the 20 cytokines (IGF-1, IL-6, IL-8, PIGF, RANTES, TGF-β1) were down-regulated in the progressive hemangioma group compared to the non- progressive hemangioma group, and there were statistically significant difference (p < 0.05): especially, IGF-...Continue Reading

References

Dec 1, 1992·Pediatric Dermatology·J B Mulliken
Mar 20, 2001·The Journal of Clinical Investigation·E BoyeJ Bischoff
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aihua LiRakesh K Singh
Nov 23, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Paula E NorthMartin C Mihm
May 29, 2010·The Journal of Dermatology·Masatoshi JinninBjorn R Olsen
Sep 28, 2010·Angiogenesis·Shoshana GreenbergerJoyce Bischoff
Jul 27, 2011·Pediatrics·Marcia HogelingOrli Wargon
Mar 7, 2014·PloS One·Daniela D'ArcangeloAntonio Facchiano
Jul 30, 2014·Plastic and Reconstructive Surgery·ChengHong JiangWenli Gu
Oct 30, 2014·Journal of Molecular Endocrinology·Leon A Bach
Jul 16, 2017·The American Journal of Pathology·Keith Q WuOlin D Liang

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Citations

May 8, 2020·Drug Discoveries & Therapeutics·Sayaka TaniMasatoshi Jinnin

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