Serum cytokines and steroidal hormones in polymyalgia rheumatica and elderly-onset rheumatoid arthritis.

Annals of the Rheumatic Diseases
M CutoloA Sulli

Abstract

Polymyalgia rheumatica (PMR) may create some difficulties in the differential diagnosis of elderly-onset rheumatoid arthritis (EORA) and of EORA with PMR-like onset (EORA/PMR). To investigate possible differences between three groups of patients, with regard to serum levels of inflammatory cytokines and steroidal hormones at baseline and after 1 month of treatment with glucocorticoids (prednisone 7.5-12.5 mg/day). 14 patients with PMR, 15 with EORA and 14 with EORA/PMR, as well as 15 healthy, matched controls were analysed. Tumour necrosis factor alpha (TNFalpha), interleukin (IL)6, IL1 receptor antagonist (IL1Ra), cortisol, dehydroepiandrosterone sulphate (DHEAS) and 17-hydroxy-progesterone (PRG) were evaluated. Serum levels of both TNFalpha and IL6 were significantly higher in all three groups of patients than in controls (p<0.01). Serum IL6 levels were significantly higher in patients with both PMR and EORA/PMR than in patients with EORA (p<0.05). IL1Ra serum levels were significantly higher in patients with EORA than in controls (p<0.001) and in patients with PMR and EORA/PMR (p<0.05). DHEAS was significantly lower in patients with EORA/PMR than in those with EORA (p<0.05). PRG was significantly higher in all patient groups...Continue Reading

References

Jul 1, 1990·Annals of the Rheumatic Diseases·M A CimminoM Broggini
Mar 1, 1987·Arthritis and Rheumatism·R G LahitaM New
Jan 1, 1974·Arthritis and Rheumatism·G C LiangL A Healey
Nov 1, 1982·Annals of Internal Medicine·T Y ChuangL T Kurland
Oct 1, 1994·The Journal of Clinical Endocrinology and Metabolism·A BélangerF Labrie
May 1, 1994·Annals of the Rheumatic Diseases·M A CimminoS Accardo
Mar 25, 1999·Archives of Internal Medicine·C M WeyandJ J Goronzy
Oct 17, 2001·Annals of the Rheumatic Diseases·J NarváezD Roig-Escofet
Sep 5, 2002·Internal Medicine·Haruyo IwadateReiji Kasukawa
Jun 10, 2003·Annals of the New York Academy of Sciences·M CutoloR H Straub
Sep 30, 2004·Best Practice & Research. Clinical Rheumatology·Carlo SalvaraniGene G Hunder

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Citations

Jan 12, 2012·Clinical Rheumatology·Nádia Emi AikawaJozélio Freire Carvalho
Aug 22, 2009·Modern Rheumatology·Nilton Salles Rosa NetoYehuda Shoenfeld
Jan 22, 2013·Drugs·Roberto CaporaliCarlomaurizio Montecucco
Oct 12, 2012·Lancet·Tanaz A Kermani, Kenneth J Warrington
Oct 31, 2007·Nature Clinical Practice. Rheumatology·Maurizio CutoloJohannes W J Bijlsma
Jul 29, 2008·Rheumatology·M CutoloA Sulli
Sep 22, 2010·Arthritis Research & Therapy·Frederik Kreiner, Henrik Galbo
Nov 3, 2012·Biologics : Targets & Therapy·Marino Paroli
Jan 18, 2016·Survey of Ophthalmology·Larry FrohmanHelen V Danesh-Meyer
Sep 3, 2010·Arthritis and Rheumatism·Frederik KreinerHenrik Galbo
Feb 28, 2009·Arthritis and Rheumatism·Elizabeth W KarlsonKaren H Costenbader
Aug 1, 2008·Arthritis and Rheumatism·Lia PulsatelliRiccardo Meliconi
Oct 19, 2011·Cytokine·Isobel R GowersAnthony G Wilson
Jan 5, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Stephen C Gilliver
Sep 10, 2014·Scottish Medical Journal·Patrick J RooneyPeter Balint
Oct 27, 2017·Rheumatology·Tanaz A Kermani, Bhaskar Dasgupta
Feb 4, 2014·Therapeutic Advances in Musculoskeletal Disease·Tanaz A Kermani, Kenneth J Warrington
May 5, 2010·The Journal of Rheumatology·Keisuke HagiharaTadamitsu Kishimoto
Apr 3, 2010·The Journal of Rheumatology·Cornelia M SpiesFrank Buttgereit
Dec 1, 2007·Arthritis and Rheumatism·Maria Grazia CatanosoCarlo Salvarani
Oct 29, 2010·Expert Review of Clinical Immunology·Parasar GhoshBhaskar Dasgupta
Feb 6, 2019·Psychiatry and Clinical Neurosciences·Bogna Grygiel-GórniakMariusz Puszczewicz
Jul 10, 2010·Scandinavian Journal of Rheumatology·F Kreiner, H Galbo
Jul 22, 2014·The Korean Journal of Internal Medicine·Masashi Ohe, Toshiyuki Bohgaki
Sep 18, 2020·Autoimmunity Reviews·Guillermo Carvajal AlegriaValérie Devauchelle-Pensec
Feb 19, 2008·Current Opinion in Rheumatology

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