Serum decoy receptor 3 level: a predictive marker for nodal metastasis and survival among oral cavity cancer patients

Head & Neck
Hsi-Feng TuKuo-Wei Chang

Abstract

Validating markers for prediction of nodal metastasis could be beneficial in treatment of oral cavity cancer. Decoy receptor 3 (DcR3), locus on 20q13, functions as a death decoy inhibiting apoptosis mediated by the tumor necrosis factor receptor (TNFR) family. This study analyzed the serum level of DcR3 in relationship to the clinical parameters of oral cavity cancer patients together with detection of DcR3 genomic copy number in primary and recurrent tumors. Elevated serum DcR3 was associated with nodal metastasis and worse prognosis. Gain of DcR3 copy number was detected in 17% of primary tumor tissue but not found in healthy areca chewers. Tissue from recurrent tumors showed more frequent DcR3 copy number alteration (48%) than the paired primary tumor tissue. Serum DcR3 level is a predictor for the nodal metastasis and survival among oral cavity cancer patients and the DcR3 copy number alteration could underlie oral carcinogenesis progression.

References

Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·C BaiC T Caskey
Oct 25, 2002·International Journal of Cancer. Journal International Du Cancer·Gabriele MildChristoph Rochlitz
Apr 23, 2003·The American Journal of Pathology·Rong WuKathleen R Cho
May 13, 2003·International Journal of Cancer. Journal International Du Cancer·Yulian WuJiangping Wu
Jul 12, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Wen-Liang LoRichard Che-Shoa Chang
Sep 17, 2004·The Journal of Pathology·Yann-Jang ChenKuo-Wei Chang
Jan 1, 2005·Acta Neuropathologica·Yasuaki ArakawaYutaka Hayashi
Apr 1, 2008·American Journal of Clinical Oncology·Yulian WuQiuping Xie
Aug 7, 2008·British Journal of Cancer·K OtaY Ando
Sep 25, 2008·Neoplasia : an International Journal for Oncology Research·Stephan Macher-GoeppingerWilfried Roth
Dec 17, 2008·Archives of Otolaryngology--head & Neck Surgery·Vipa BoonkitticharoenLucksana Pochanukul
Aug 19, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Deepak KademaniJeffrey R Harrington

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis