Serum deprivation induced apoptosis in macrophage is mediated by autocrine secretion of type I IFNs

Apoptosis : an International Journal on Programmed Cell Death
J WeiJ Gu

Abstract

Apoptosis can be triggered by different forms of cellular stress. We here show that serum deprivation induces the expression and secretion of type I interferons and results in apoptosis in RAW 264.7 cell in a caspase dependent manner. Administration of either IFN-alpha or IFN-beta antibody partially inhibits apoptosis while the two antibodies used together totally prevents RAW264.7 cell from apoptosis. GM-CSF, but not M-CSF and IL-3, protects serum deprivation induced apoptosis. Inhibition of JAKs also prevents macrophages from apoptosis. Activation of MAPKs is not required for serum deprivation induced apoptosis. Our results are the first to demonstrate that serum deprivation-induced apoptosis acts through autocrine secretion of type I interferons.

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Citations

Aug 23, 2011·Apoptosis : an International Journal on Programmed Cell Death·Andrea SgorbissaClaudio Brancolini
Mar 21, 2007·Journal of Leukocyte Biology·Tricia H BurdoHoward S Fox
Jan 12, 2011·Biochemical and Biophysical Research Communications·Hiroyuki SuganumaPaul Talalay
Jun 26, 2007·Biochemical and Biophysical Research Communications·Katsutoshi MiyatakeMitsuo Itakura
Feb 20, 2007·Experimental Cell Research·Tobias NyströmAnna Hultgårdh-Nilsson

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