Serum dioxin concentrations and time to pregnancy.

Epidemiology
Brenda EskenaziPaolo Mocarelli

Abstract

Pollution may play a role in population trends of declining semen quality and regional differences in time to pregnancy (TTP) in industrialized societies. Dioxins including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been suspected. In 1976, an explosion near Seveso, Italy resulted in the highest TCDD exposure known in residential populations. Twenty years later, we conducted a retrospective cohort study, the Seveso Women's Health Study. Of 981 participants, 472 women attempted pregnancy after the explosion, and 278 delivered a livebirth not associated with contraceptive failure. Individual serum TCDD levels were measured from samples collected soon after the explosion and extrapolated to the conception attempt. We examined the relation of TCDD levels to time to pregnancy (parameterized as the monthly probability of conception within the first 12 months of trying) and to infertility (defined as conception after at least 12 months of trying). We modeled fecundability with discrete-time Cox proportional hazards regression, and we modeled fertility with logistic regression. We tested the sensitivity of the conclusions to differing definitions of eligibility and outcome. Median TCDD level was 50 parts per trillion, median time ...Continue Reading

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Citations

Nov 16, 2012·Environmental Health Perspectives·Germaine M Buck LouisDana B Barr
Dec 7, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Germaine M Buck Louis
Jan 1, 2014·Endocrine Disruptors·Tracie R BakerWarren Heideman
Dec 3, 2013·Environment International·Amelia WesselinkBrenda Eskenazi
Mar 19, 2015·PloS One·Ina Olmer SpechtKristian T Jørgensen
Jul 15, 2016·Human Reproduction·Melissa M SmarrGermaine M Buck Louis
Nov 20, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Laurentius Ron Hoogenboom
Mar 31, 2017·The Journal of Endocrinology·Saniya RattanJodi A Flaws
Nov 5, 2020·Human Reproduction Update·Linda G KahnUNKNOWN program collaborators for Environmental Influences on Child Health Outcomes Program
Jan 16, 2021·International Journal of Molecular Sciences·Masutaka FurueGaku Tsuji
Feb 10, 2018·Environmental Research·Germaine M Buck LouisKurunthachalam Kannan
Aug 28, 2021·International Journal of Molecular Sciences·Laura GaspariSamir Hamamah

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