Serum EGF-receptor and HER-2 extracellular domains and prognosis of non-small-cell lung cancer

British Journal of Cancer
W JacotP-J Lamy

Abstract

This retrospective study aimed at evaluating the prognostic impact of high serum levels of either the HER-2 extracellular domain (ECD) or the epidermal growth factor receptor (EGFR) ECD measured using two specific ELISAs in 221 patients with non-small-cell lung cancer (NSCLC) receiving conventional therapy and 41 nonmalignant pulmonary diseases patients. It was not possible to discriminate between lung cancer and benign lung disease owing to the lack of sensitivity-specificity relationship of HER-2 and EGFR ECD levels. Neither HER-2 nor EGFR ECD specific levels were associated with a particular prognosis of NSCLC patients receiving conventional therapy.

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Citations

Jan 1, 2009·Expert Review of Clinical Pharmacology·Rachel E Sanborn, Angela M Davies
Apr 25, 2007·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Katya RubiaEric Taylor
Mar 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William L BigbeeJill M Siegfried

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

AccuROC

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