Serum elastin-derived peptides and anti-elastin antibody in patients with systemic sclerosis.

Journal of Korean Medical Science
Yoo Jin HongYeong Wook Song

Abstract

The elastin metabolism in systemic sclerosis (SSc) has been known to be abnormal. The authors investigated relationship between the clinical manifestations of systemic sclerosis (SSc) and serum levels of soluble elastin-derived peptide (S-EDP) and anti-elastin antibodies. Serum samples were obtained from 79 patients with SSc and 79 age- and sex-matched healthy controls. Concentrations of serum S-EDP and anti-elastin antibodies were measured by ELISA. The serum concentrations of S-EDP in SSc patients were significantly higher than in healthy controls (median, 144.44 ng/mL vs 79.59 ng/mL, P < 0.001). Serum EDP concentrations were found to be correlated with disease duration in SSc (P = 0.002) and particularly in diffuse cutaneous SSc (P = 0.005). Levels of anti-elastin antibodies were found to be more elevated in SSc patients than in healthy controls (median, 0.222 U vs 0.191 U, P = 0.049), more increased in diffuse cutaneous SSc than limited cutaneous SSc (median, 0.368 U vs 0.204 U, P = 0.031). In addition, levels of anti-elastin antibodies were also found to be negatively associated with presence of anti-centromere antibody (P = 0.023). The S-EDP levels were not found to be correlated with levels of anti-elastin antibodies. Th...Continue Reading

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Citations

Mar 7, 2014·Equine Veterinary Journal·K de KeyserN Buys
Mar 25, 2016·Cardiovascular Research·Laurent DucaPascal Maurice
Oct 25, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Charlotte KaweckiPascal Maurice
Jan 7, 2014·Annals of the Rheumatic Diseases·Pia MoinzadehUNKNOWN all participating DNSS centers
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Nov 10, 2018·Seminars in Arthritis and Rheumatism·N ChamptiauxUNKNOWN Groupe d'Etudes et de Recherche sur les Maladies « Orphelines » pulmonaires (GERM«O»P)

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
bronchoalveolar lavage

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