Serum enterolactone concentration and the risk of coronary heart disease in a case-cohort study of Finnish male smokers

American Journal of Epidemiology
Annamari KilkkinenJarmo Virtamo

Abstract

The lignan enterolactone produced by the intestinal microflora from dietary precursors has been hypothesized to protect against coronary heart disease. The present study examined the association between serum enterolactone concentration and the risk of coronary heart disease. A prospective case-cohort study was conducted among male smokers randomized to receive a placebo supplement in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (1986-1999). Serum enterolactone concentrations were measured by the gas chromatography-mass spectrometry method in serum collected at trial baseline from 340 men diagnosed with nonfatal myocardial infarction (n = 205) or coronary death (n = 135) during follow-up and from the randomly selected subcohort of 420 subjects. The classic risk factors-adjusted rate ratios for all coronary heart disease events in increasing quintiles of enterolactone were 1.00 (referent), 0.85 (95% confidence interval (CI): 0.51, 1.43), 0.59 (95% CI: 0.35, 1.00), 0.69 (95% CI: 0.40, 1.16), and 0.63 (95% CI: 0.33, 1.11), and the p(trend) was 0.07. For the highest versus the lowest quintile of enterolactone, the rate ratios for nonfatal myocardial infarction and coronary death were 0.67 (95% CI: 0.37, 1.23; p(trend...Continue Reading

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Citations

Oct 5, 2010·Nutrition Reviews·Julia PetersonMarjorie L McCullough
Oct 19, 2007·Critical Reviews in Clinical Laboratory Sciences·Herman Adlercreutz
Sep 24, 2015·Andrologia·F Comhaire, A Mahmoud
Aug 9, 2008·Atherosclerosis·Anneleen KuijstenPeter C H Hollman
May 23, 2018·Critical Reviews in Food Science and Nutrition·Arpita Banerjee, Pubali Dhar
Dec 29, 2018·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Sherif ArafaAdel Abdel-Ghaffar
May 1, 2020·Bioscience Reports·Bo ZhangChunsheng Li
Feb 26, 2010·The American Journal of Clinical Nutrition·Kerstin KempfJaakko Tuomilehto
Feb 9, 2008·The American Journal of Clinical Nutrition·Iris ErlundAntti Jula
Apr 24, 2007·The Journal of Nutrition·Petra H M PeetersSheila A Bingham
Feb 11, 2021·International Journal of Molecular Sciences·Rami S Najjar, Rafaela G Feresin
Jan 16, 2010·Journal of Agricultural and Food Chemistry·Raika KoliGeorg Alfthan
Nov 21, 2021·European Journal of Nutrition·Lucia Rizzolo-BrimeRaul Zamora-Ros

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