Serum enzymes of lysosomal origin as indicators of the metabolic control in diabetes: comparison with glycated hemoglobin and albumin

Acta diabetologica latina
G GoiD Gaburro

Abstract

Several lysosomal enzymes (beta-N-D-acetylglucosaminidase, beta-D-glucuronidase, alpha-D-galactosidase, beta-D-galactosidase, alpha-L-fucosidase, alpha-D-glucosidase, alpha-D-mannosidase, beta-D-glucosidase), glycated albumin and glycated hemoglobin (HbA1c) were determined in the serum of 81 insulin-dependent diabetics with different degrees of metabolic control (optimal, 21 patients; good, 39 patients; poor, 21 patients) and without signs of complications, and in 42 control subjects. All parameters examined increased in serum in inverse proportion to the degree of metabolic control. A highly significant correlation (p less than 0.01) was found between lysosomal enzymes and both glycated albumin and HbA1c. All parameters correlated with hyperglycemia, glycated albumin having the highest r-value (0.586) and lysosomal enzymes the lowest one. Unlike glycated albumin and HbA1c, serum levels of lysosomal enzymes in patients with optimal metabolic control were undistinguishable or even lower than those of controls. A 2-month longitudinal monitoring of a patient who was hospitalized in conditions of poor metabolic control and adequately treated, proved that lysosomal enzymes diminished in serum parallel to glycated albumin and HbA1c i...Continue Reading

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Citations

Feb 15, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·B HultbergC D Agardh
Jan 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·G GoiA Lombardo
Mar 29, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·A LombardoA Burlina
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Oct 1, 1995·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·G GoiG Tettamanti
Apr 15, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Anna V OláhJózsef Varga
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Mar 31, 2018·Archives of Insect Biochemistry and Physiology·Natalia N PerrellaAdriana R Lopes
Jun 21, 2008·Orvosi hetilap·Petra VargaEva Oláh

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