Abstract
Several lysosomal enzymes (beta-N-D-acetylglucosaminidase, beta-D-glucuronidase, alpha-D-galactosidase, beta-D-galactosidase, alpha-L-fucosidase, alpha-D-glucosidase, alpha-D-mannosidase, beta-D-glucosidase), glycated albumin and glycated hemoglobin (HbA1c) were determined in the serum of 81 insulin-dependent diabetics with different degrees of metabolic control (optimal, 21 patients; good, 39 patients; poor, 21 patients) and without signs of complications, and in 42 control subjects. All parameters examined increased in serum in inverse proportion to the degree of metabolic control. A highly significant correlation (p less than 0.01) was found between lysosomal enzymes and both glycated albumin and HbA1c. All parameters correlated with hyperglycemia, glycated albumin having the highest r-value (0.586) and lysosomal enzymes the lowest one. Unlike glycated albumin and HbA1c, serum levels of lysosomal enzymes in patients with optimal metabolic control were undistinguishable or even lower than those of controls. A 2-month longitudinal monitoring of a patient who was hospitalized in conditions of poor metabolic control and adequately treated, proved that lysosomal enzymes diminished in serum parallel to glycated albumin and HbA1c i...Continue Reading
References
Sep 1, 1978·Diabetes·E C AbrahamT H Huisman
May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·K H GabbayP M Gallop
Feb 18, 1971·The New England Journal of Medicine·L A TrivelliH T Lai
Dec 22, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·A LombardoG Tettamanti
Jun 1, 1984·Pediatric Clinics of North America·D M Kirschenbaum
Jul 1, 1983·Acta diabetologica latina·G PerdichizziG Squadrito
Jan 1, 1984·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·Y S ShinW Endres
Jun 1, 1980·Diabetes·R Dolhofer, O H Wieland
Jun 3, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M MirallesA Reglero
Dec 1, 1982·Hoppe-Seyler's Zeitschrift für physiologische Chemie·R DolhoferO H Wieland
Aug 1, 1981·Diabetologia·L KennedyT J Merimee
Jul 1, 1981·Acta diabetologica latina·E KohlerT A Good
Citations
Oct 1, 1992·Diabetologia·P J WatersC A Pennock
Oct 1, 1988·Acta diabetologica latina·G GoiG Tettamanti
Apr 1, 1987·Acta diabetologica latina·G PerdichizziG Squadrito
Oct 1, 1987·Acta diabetologica latina·G GoiG Tettamanti
Feb 15, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·B HultbergC D Agardh
Nov 30, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·G GoiA Lombardo
Jan 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·G GoiA Lombardo
Mar 29, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·A LombardoA Burlina
Dec 1, 1987·Clinical Biochemistry·A B BurlinaG Tettamanti
Jan 7, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·G GoiA Burlina
Jul 27, 1999·Metabolism: Clinical and Experimental·G GoiA Lombardo
Oct 1, 1992·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·G GoiG Tettamanti
Oct 1, 1995·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·G GoiG Tettamanti
Apr 15, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Anna V OláhJózsef Varga
Dec 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation·B HultbergC D Agardh
Nov 1, 2016·American Journal of Medical Genetics. Part a·Carlos R FerreiraKristina Cusmano-Ozog
Mar 31, 2018·Archives of Insect Biochemistry and Physiology·Natalia N PerrellaAdriana R Lopes
Jun 21, 2008·Orvosi hetilap·Petra VargaEva Oláh
Feb 18, 1999·The Journal of Clinical Endocrinology and Metabolism·M CostelloC D Scott
Sep 1, 1996·Annals of Clinical Biochemistry·B HultbergL Brattström