Serum eosinophil granule proteins predict asthma risk in allergic rhinitis

Allergy
L P NielsenR Dahl

Abstract

Allergic rhinitis is a common disease, in which some patients will deteriorate or develop asthma. It is important to characterize these patients, thereby offering the possibility for prevention. This study evaluated eosinophil parameters as potential indicators of deteriorating allergic airway disease. The subjects of the study included all patients who suffered seasonal allergic rhinitis and had participated in a study 6 years earlier, in which blood eosinophils, serum eosinophil cationic protein (ECP) serum eosinophil peroxidase (EPO), nasal lavage ECP and nasal lavage EPO levels were measured. Patients in the present study were interviewed on occurrence of rhinitis symptoms during the last season, rhinitis outside season, asthma-like symptoms and asthma diagnosis, and were skin-prick tested for common aeroallergens. Eosinophil parameters from the study 6 years earlier were then tested for the ability to predict occurrence of new allergies, worsening of rhinitis and occurrence of asthma. Forty-four patients participated in the study. In four patients seasonal rhinitis symptoms had deteriorated, 10 had experienced perennial rhinitis symptoms, 14 reported asthma-like symptoms and seven had been diagnosed with asthma. Thirteen h...Continue Reading

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Citations

Aug 7, 2013·Current Allergy and Asthma Reports·Zuzana DiamantLeif Bjermer
May 13, 2014·The Tohoku Journal of Experimental Medicine·Jae-Woo JungSeong-Wook Sohn
Aug 7, 2013·Clinical Pharmacology and Therapeutics·C-P Milne
Oct 17, 2017·Frontiers in Medicine·Emma DoranJoseph R Arron
Sep 1, 2017·Genome Biology and Evolution·Matthew F BarberNels C Elde
Jan 14, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery
Dec 23, 2009·Current Opinion in Allergy and Clinical Immunology

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