Serum erythropoietin and erythropoiesis during six years after kidney transplantation

Nephron
J GochB G Danielson

Abstract

We have studied serum erythropoietin (EPO) levels during 6 years after kidney transplantation in 16 patients. There was a serum EPO peak around 50 mU/ml after 5 weeks. After 3 months the serum EPO level stabilized at around 30 mU/ml. Patients with good transplant function had significantly higher serum EPO levels and normalized their hemoglobin (Hb) after a mean of 3 months. If transplant function was good, Hb was normalized even if the serum EPO was only slightly elevated. Patients with poor transplant function had lower serum EPO and Hb levels. We concluded that a good transplant function is the key to a normal erythropoiesis and that small amounts of EPO are needed to improve Hb.

Citations

Oct 31, 2008·European Journal of Clinical Pharmacology·Stuart A McCluskeyKeyvan Karkouti
Nov 5, 2003·American Journal of Veterinary Research·Lillian R AronsonUrs Giger
Mar 22, 2007·Kidney & Blood Pressure Research·Josef ZadrazilMiroslav Hrubý
Dec 16, 1998·Molecular Genetics and Metabolism·J C WhitinH J Cohen
Apr 9, 2015·Frontiers in Cell and Developmental Biology·Yu YangYun Chen

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