Serum essential trace elements and toxic metals in Chinese diabetic retinopathy patients

Medicine
Xinmiao Zhu, Rui Hua

Abstract

Trace elements are essential for the proper functioning of proteins, enzymes, and transcriptional factors. However, toxic metals will compete with essential trace elements, and damage enzymatic activities and various physiological functions. We aimed to investigate the status of serum essential trace elements and toxic metals in Chinese diabetic retinopathy (DR) patients, and to analyze their associations.This retrospective study included 33 normal subjects (normal group), 44 type 2 diabetes mellitus (T2D) patients with DR (DR group), and 58 T2D patients without DR (diabetes mellitus [DM] group). Serum levels of zinc (Zn), manganese (Mn), cadmium (Cd), and cesium (Cs), were measured for all participants using inductively coupled plasma-mass spectrometry.The serum concentrations of Mn (0.0226 μg/L) and Zn (98.162 μg/L) were significantly lower in DR group, compared with both the DM group and normal group (P < 0.05). In contrast, the serum levels of Cs (0.0354 μg/L) and Cd (0.0149 μg/L) were significantly higher in DR group, compared with the normal group (Cs: z = 3.136, P = .002; Cd: z = 3.766, P < .0001). Similarly, the serum Cs level in the DM group was 0.0323 μg/L, which was significantly higher than that in the normal group ...Continue Reading

References

Jan 15, 2008·Biological Trace Element Research·Tasneem Gul KaziGhulam Abbas Kandhro
Jan 12, 2010·International Journal of Diabetes in Developing Countries·Muhittin A SerdarMetin Yildirimkaya
May 22, 2010·Diabetologia·J Rungby
Jul 21, 2012·Diabetes & Metabolic Syndrome·Dimitry A Chistiakov
Nov 14, 2013·Biological Trace Element Research·Giovanni ForteRoberto Madeddu
Dec 10, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ching-Chiang LinYeou-Lih Huang
Jan 1, 2014·World Journal of Diabetes·Lihteh WuMarissé Masis
Jan 10, 2014·Journal of Diabetes and Metabolic Disorders·Abdul Rehman Khan, Fazli Rabbi Awan

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