Serum Fas and Bcl-2 in patients with epilepsy

Acta Neurologica Scandinavica
M A El-HodhodS M Samaan

Abstract

The present study aimed to investigate the levels of the biochemical markers of apoptosis (soluble Fas and Bcl-2) in the sera of children and adolescents with idiopathic epilepsy. The study included 30 children and adolescents (mean age 8.03 +/- 4.49 years) with idiopathic epilepsy, 16 of them were newly diagnosed, and 15 clinically healthy control subjects. Of the included patients, 22 had focal seizures and eight had generalized seizures. In addition to laboratory and radiological investigations needed for diagnosis and follow-up, soluble Fas (s.Fas) and Bcl-2 were assayed in sera of patients and controls by enzyme-linked immunosorbent assay technique. Serum levels of s.Fas and Bcl-2 were significantly higher in the patients group than in the control group; however, their levels were comparable in patients with different seizure types. Levels of s.Fas correlated positively with seizure severity and negatively with the duration from the last attack. Bcl-2 levels were positively correlated to each of the duration of epilepsy, the severity of seizures and its frequency. There was a significant positive correlation between serum levels of s.Fas and that of Bcl-2 and both were significantly increased in patients with uncontrolled ...Continue Reading

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Citations

Dec 15, 2010·Journal of Bioenergetics and Biomembranes·Shang-Der ChenYao-Chung Chuang
Apr 7, 2011·Experimental & Molecular Medicine·Chang Hoon Cho
Feb 22, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Euteum ParkHong Sung Chun
Mar 1, 2012·Seizure : the Journal of the British Epilepsy Association·Ayman KilanyM Osama Abdulghani
Jun 12, 2020·Epilepsia Open·Pablo M Casillas-EspinosaTerence J O'Brien
May 1, 2021·International Journal of Environmental Research and Public Health·Ella NissanNicola Luigi Bragazzi

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