Serum ferritin-a novel risk factor in acute myocardial infarction.

Indian Heart Journal
M P HolayS D Suryawanshi

Abstract

A possible association between body iron status and risk of coronary heart disease (CHD) has been found to be controversial from the data obtained from various studies. To study the relationship of serum ferritin with acute myocardial infarction (AMI) in univariate and multivariate analysis and to assess the relationship of high serum ferritin with established conventional risk factors. Hospital based case-control study of 75 cases of AMI, and 75 age and equal number of age, and gender-matched controls without having AMI in the age group of 30-70 years. Median serum ferritin levels were significantly higher in cases (220 μg/L) than controls (155 μg/L) (P ≤ 0.0001. In univariate analysis in addition to ferritin > 200 μg/L (odds ratio [OR] 6.71, 95% confidence interval [CI] = 3.22-12.89, P<0.05), diabetes (OR=7.68, 95% CI=2.95-19.13, P<0.05), hypertension (HTN) (OR=2.36, 95% CI=1.02-5.14, P<0.05) high-density lipoprotein (HDL) < 35 mg/dL (OR = 11.9, 95% CI = 2.66-52.57, P<0.05) and smoking (OR=2.17, 95% CI = 1.12-3.87, P< 0.05) were found to be significantly associated with AMI. After controlling for all conventional risk factors, in multiple logistic regression analysis, high ferritin was significantly associated with AMI. (adju...Continue Reading

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Citations

Sep 24, 2013·Current Atherosclerosis Reports·Emanuela LapiceOlga Vaccaro
Jul 17, 2013·Nutrients·Carlos Muñoz-BravoJoaquín Fernández-Crehuet Navajas
Feb 20, 2014·Metallomics : Integrated Biometal Science·Douglas B Kell, Etheresia Pretorius
Jan 26, 2016·International Journal of Molecular Sciences·Raffaella Gozzelino, Paolo Arosio
May 23, 2014·Frontiers in Pharmacology·Francesca VinchiViktória Jeney
Sep 9, 2016·Physiological Reviews·Anita AyerRoland Stocker
Dec 24, 2019·Expert Review of Gastroenterology & Hepatology·Vassilios A SevastianosSpyros P Dourakis
May 20, 2020·Revista da Associação Médica Brasileira·Shuang WenChangwei Liu
Mar 25, 2019·European Heart Journal·Francesca VinchiMartina U Muckenthaler
Jan 26, 2021·Drug Discovery Today·Prakash VasanthiDharmalingamRajarajan A Thandavarayan

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