Serum ferritin as a predictor of the acute respiratory distress syndrome

American Journal of Respiratory and Critical Care Medicine
K G ConnellyJ E Repine

Abstract

We investigated serum ferritin levels as a predictor of the acute respiratory distress syndrome (ARDS) because: (1) proinflammatory cytokines, which are implicated in ARDS, increase ferritin synthesis; and (2) oxidative stress in patients at risk for ARDS might liberate iron from ferritin, accelerating toxic hydroxyl radical (.OH) formation. Serum ferritin levels measured by radioimmunoassay (RIA) were greater in 75 patients at risk for ARDS (women, p < 0.0001; men, p < 0.0001) and 8 patients with ARDS (women, p = 0.001; men, p = 0.0009) than in healthy control subjects. Serum ferritin levels were also greater in female (p = 0.003) and male (p = 0.003) at-risk patients who developed ARDS than in patients who did not develop ARDS. In women, a value exceeding 270 ng/ml predicted ARDS with an 83% sensitivity, 71% specificity, 67% positive, and 86% negative predictive value. In men, a value exceeding 680 ng/ml predicted ARDS with a 60% sensitivity, 90% specificity, 75% positive, and 82% negative predictive value. Serum ferritin levels did not correlate with C-reactive protein levels, were not different in medical or surgical at-risk patients, and were not accounted for by liver disease. Evaluating serum ferritin levels in at-risk p...Continue Reading

Citations

Jan 7, 2000·Resuscitation·T H RainerR A Cocks
Oct 3, 1999·Critical Care Medicine·M A MatthayH Ischiropoulos
May 11, 2002·Critical Care Medicine·Lance S Terada
Jul 20, 2002·Critical Care Medicine·Marino FestaGregory J Quinlan
Jan 21, 2006·Critical Care Medicine·Cristiane RitterFelipe Dal-Pizzol
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·R A SharkeyJ E Repine
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·A D BerstenI R Doyle
Jun 24, 2005·Respiratory Research·Argyris TzouvelekisDemosthenes Bouros
Feb 20, 2014·Metallomics : Integrated Biometal Science·Douglas B Kell, Etheresia Pretorius
Sep 16, 2000·Chest·A J GhioJ D Carter
Dec 23, 2008·Biochimica Et Biophysica Acta·Andrew J Ghio
Nov 25, 2003·The Journal of Investigative Dermatology·Sim Yeoh-Ellerton, Michael C Stacey
Nov 19, 2008·The Journal of Allergy and Clinical Immunology·Gyu-Young HurHae-Sim Park
Aug 1, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Taiichi WakiyaKoichi Mizuta
Dec 4, 2003·Clinical and Laboratory Haematology·D O'ShaughnessyM Shearer
Jun 25, 2008·Chest·Polly E Parsons
Jun 21, 1997·Lancet·L D Hudson, T R Martin
Mar 14, 2009·Journal of Intensive Care Medicine·Joseph E LevittMichael A Matthay
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Yoon-Yub Park
Dec 7, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna L LaganGregory J Quinlan
Oct 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Funmei YangAndrew J Ghio
Feb 20, 2019·Pharmaceuticals·Vida ZhangAirie Kim
Apr 1, 2016·Expert Review of Proteomics·Joseph E Levitt, Angela J Rogers
Sep 10, 2020·Revista Do Instituto De Medicina Tropical De São Paulo·Hareton Teixeira VechiManoella do Monte Alves
Jan 8, 2020·International Journal of Molecular Sciences·Sara OttolenghiAnna Caretti
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·M A LevyT M Bray
Jul 1, 2020·Physiological Reports·Vida ZhangAirie Kim
Sep 11, 2020·The Journal of Biological Chemistry·Bowen YuYongning He
Dec 18, 2020·Revista Do Instituto De Medicina Tropical De São Paulo·Hareton Teixeira VechiJoão Firmino Rodrigues-Neto
Dec 31, 2020·Journal of Medical Virology·Marine GilisKevin Bouiller
May 25, 2021·Frontiers in Medicine·Mengdi QuChanghong Miao
Jul 3, 2021·Sensors·Reena Sri SelvarajanAzrul Azlan Hamzah
Apr 28, 2020·Médecine et maladies infectieuses·J RazanamaheryK Bouiller

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.