Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.

American Journal of Hematology
V R GordeukF W Dawkins

Abstract

How often elevated serum ferritin in primary-care patients reflects increased iron stores (normally 0.8 g in men, 0.4 g in women) is not known. The Hereditary Hemochromatosis and Iron Overload Screening (HEIRS) study screened 101,168 primary-care participants (44% Caucasians, 27% African-Americans, 14% Asians/Pacific Islanders, 13% Hispanics, 2% others). Follow-up clinical evaluation was performed in 302 of 333 HFE C282Y homozygotes regardless of iron measures and 1,375 of 1,920 nonhomozygotes with serum ferritin >300 microg/L (men), >200 microg/L (women) and transferrin saturation >50% (men), >45% (women). Quantitative phlebotomy was conducted in 122 of 175 C282Y homozygotes and 122 of 1,102 nonhomozygotes with non-transfusional serum ferritin elevation at evaluation. The estimated prevalence in the Caucasian population of C282Y homozygotes with serum ferritin >900 microg/L at evaluation was 20 per 10,000 men and 4 per 10,000 women; this constellation was predictive of iron stores >4 g in men and >2 g in women. The estimated prevalence per 10,000 of non-C282Y homozygotes with serum ferritin >900 microg/L at evaluation was 7 among Caucasians, 13 among Hispanics, 20 among African Americans, and 38 among Asians and Pacific Island...Continue Reading

References

Jan 1, 1979·Nutrition and Metabolism·E Björn-Rasmussen, L Hallberg
Jun 1, 1992·Gastroenterology·A M Di BisceglieB R Bacon
Jun 7, 1986·Lancet·V R GordeukG M Brittenham
Oct 20, 1988·The New England Journal of Medicine·R G StevensP R Taylor
Oct 1, 1973·Journal of Clinical Pathology·G O WaltersM Worwood
May 30, 1974·The New England Journal of Medicine·D A LipschitzC A Finch
Mar 1, 1968·Annals of Internal Medicine·S P BalcerzakF H Taylor
Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B TurlinY Deugnier
Jul 27, 1999·The British Journal of Dermatology·D CreamerJ L Hawk
Mar 1, 2000·American Journal of Epidemiology·D O StramL N Kolonel
Apr 12, 2001·Seminars in Liver Disease·Y Falck-YtterA J McCullough
Feb 18, 2003·The American Journal of the Medical Sciences·Christine E McLarenUNKNOWN Hemochromatosis and Iron Overload Study Research Investigators
Aug 20, 2003·Biostatistics·Todd A AlonzoThomas Lumley
Jun 1, 1956·The Journal of Clinical Investigation·K R REISSMANN, M R DIETRICH
Dec 7, 1964·JAMA : the Journal of the American Medical Association·J A PRITCHARD, R A MASON
Sep 23, 2003·The American Journal of Gastroenterology·Bret L HickenJames C Barton
Feb 12, 2004·JAMA : the Journal of the American Medical Association·Rui JiangFrank B Hu
Jun 1, 1952·The Journal of Clinical Investigation·D HASKINSC A FINCH
Jun 4, 2004·The New England Journal of Medicine·Antonello Pietrangelo
Apr 29, 2005·The New England Journal of Medicine·Paul C AdamsUNKNOWN Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators
Feb 24, 2006·American Journal of Hematology·Massimo Franchini
Jun 29, 2007·American Journal of Hematology·Christine E McLarenUNKNOWN Hemochromatosis and Iron Overload Screening Study Research Investigators
Oct 30, 2007·American Journal of Hematology·Pierre Brissot

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Citations

Apr 15, 2011·Genetics and Molecular Research : GMR·I F EstevãoC R Bonini-Domingos
Dec 18, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Arch G MainousAlthea M Grant
Mar 25, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·James C BartonC Bruce Alexander
Oct 12, 2011·Transfusion·Nadine A BertalliUNKNOWN HealthIron Study Investigators
Jan 22, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christine E McLarenGordon D McLaren
Jul 15, 2015·European Journal of Human Genetics : EJHG·Graça PortoSteve Keeney
May 18, 2010·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Dec 7, 2011·American Journal of Preventive Medicine·Mary M HulihanAlthea M Grant
Apr 23, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Thomas P MoyerJohn B Gross
Dec 17, 2009·Nature Reviews. Endocrinology·Kristina M Utzschneider, Kris V Kowdley
Apr 18, 2018·British Journal of Haematology·Edward J FitzsimonsUNKNOWN British Society for Haematology
Jun 3, 2021·Journal of Clinical Medicine·Miriam SandnesHåkon Reikvam

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