Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis

Biomedical Reports
Jixu YuWei Li

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. The mechanism that defines the loss of neurons in ALS is still not clearly understood, and there is no effective therapy to block its progression. Previous studies indicate that a disorder of iron homeostasis exists in ALS and based on this, the change of serum iron and ferritin and the association between iron metabolism and clinical features in Chinese Han patients with ALS was further investigated in the present study, in order to define its pathogenesis. Two cohorts were established: An ALS group consisting of 24 patients and a control group consisting of 38 healthy volunteers. Venous blood samples were collected for serum iron and ferritin analysis. The results indicated that the levels of serum iron were significantly decreased in patients with ALS (P<0.05), while there was no significant difference in serum ferritin between the ALS and control groups. However, the levels of serum ferritin were increased significantly in ALS patients with bulbar-onset (vs. limb-onset in females), dysphagia (vs. without dysphagia), longer disease duration (>12 months vs. ≤12 months in males) and lower ALS Functional Rating Scale-Revised score (<33 vs. ≥33; P<0.05). These r...Continue Reading

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Citations

Dec 29, 2019·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Motoko Niida-KawaguchiNoriyuki Shibata
Apr 25, 2020·Microorganisms·Ana C MoreiraMaria Salomé Gomes
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May 1, 2021·International Journal of Molecular Sciences·Karolina ZiabskaTeresa Zalewska

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