Serum ferritin is a major determinant of lipid phenotype in familial combined hyperlipidemia and familial hypertriglyceridemia

Metabolism: Clinical and Experimental
Rocío Mateo-GallegoFernando Civeira

Abstract

Familial combined hyperlipidemia (FCH) and familial hypertriglyceridemia (FHTG) share pathogenic mechanisms and a high interaction with components of the metabolic syndrome. The metabolic syndrome associates increased serum ferritin concentration and high cardiovascular risk. The objective was to describe the frequency of iron overload and the relationship between serum ferritin and the phenotype in patients with FCH and FHTG. The study was composed of 211 consecutive unrelated patients aged at least 18 years with primary hypertriglyceridemia, 149 with FCH, and 62 with FHTG. The prevalence of the metabolic syndrome and hyperferritinemia was very high in both hypertriglyceridemic groups (51.7% and 20.1% in FCH and 62.9% and 16.1% in FHTG, respectively), without significant statistical differences between them. Serum ferritin concentration did not show any significant association with the number of metabolic syndrome criteria. Subjects in the highest tertile of ferritin concentration (ferritin >200 mug/L) presented higher concentrations of triglycerides and liver enzymes than subjects in the first tertile of ferritin concentration (ferritin <90 mug/L). The highest positive correlation coefficient for triglycerides was found with ...Continue Reading

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Citations

Jul 21, 2010·Journal of Physiology and Biochemistry·Rocio Mateo-GallegoFernando Civeira
May 12, 2012·Current Opinion in Lipidology·Nick Wlazlo, Marleen M J van Greevenbroek
Jan 26, 2016·Metabolic Syndrome and Related Disorders·Harry Robberecht, Nina Hermans
Sep 19, 2015·Taiwanese Journal of Obstetrics & Gynecology·Po-Chun KoChun-Sen Hsu
Dec 15, 2010·Medicina clínica·Jesús MillánUNKNOWN en nombre de la Organización R3i (Residual Risk Reduction initiative) de España
Sep 18, 2010·Metabolism: Clinical and Experimental·Paola Casanova-EstebanFernando Civeira
Sep 24, 2014·Journal of Endocrinological Investigation·Z A YeginG T Sucak
Apr 18, 2014·Nutrition Research and Practice·Yan-Chao WangYong-Xiang Wang
Dec 18, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jonghan KimMarianne Wessling-Resnick
Jul 19, 2020·BMC Gastroenterology·Jessica SeeßleUta Merle

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