Serum ferritin is associated with arterial stiffness in hemodialysis patients: results of a 3-year follow-up study

International Urology and Nephrology
Kao-Chang LinChien-An Chen

Abstract

Iron may contribute to vascular injury through reactive oxygen species. Hemodialysis patients frequently receive iron supply for correction of anemia and are at a high risk of cardiovascular disease. We tested the relationship between iron status and change in arterial stiffness in hemodialysis patients. We measured iron status in 53 hemodialysis patients and studied the association with clinical, biochemical, and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) over 3 years. The blood pressure was controlled to below 140/90 mmHg by anti-hypertensive drugs. Median and interquartile range of baseline baPWV, baPWV at 3 years, and ΔbaPWV (difference between 3-year baPWV and baseline baPWV) were following: 17.6 (14.8-18.9), 16.9 (15.3-19.9), and 0.2 (-1.2 to 2.7) m/s. At baseline, baPWV was positively correlated with age, serum ferritin, and systolic blood pressure in univariate analysis. However, in multivariate analysis, only age and serum ferritin remained the significant determinants of baseline baPWV. After 3 years, ΔbaPWV was negatively correlated with age and positively with 3-year averaged serum ferritin in univariate analysis. Then, in multivariate analysis, only 3-year averaged serum ferritin was ...Continue Reading

References

Jun 13, 1981·Lancet·J L Sullivan
Jul 1, 1995·Hypertension·M O'Rourke
Mar 1, 1994·Epidemiology·H I MorrisonD T Wigle
Mar 1, 1994·Coronary Artery Disease·B C SolymossL Campeau
Jun 1, 1994·Circulation·D M BaerL B Hurley
May 11, 1999·Circulation·J BlacherG M London
Oct 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P S LimB Kho
Nov 27, 2002·The American Journal of Clinical Nutrition·Usha RamakrishnanAryeh D Stein
Jan 24, 2003·Diabetes·Eiji KimotoYoshiki Nishizawa
Oct 22, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira YamashinaSaburoh Hori
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kamyar Kalantar-ZadehMichael H Humphreys
Jan 17, 2004·Stroke; a Journal of Cerebral Circulation·Birger WolffStephan B Felix
Mar 3, 2004·Vascular Medicine·Gautam RamakrishnaLeslie T Cooper
Sep 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tokuyuki KitaharaYoshihisa Nojima
May 9, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN KDOQI, UNKNOWN National Kidney Foundation
Feb 15, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Amedeo F de VecchiFabrizia Bamonti
Sep 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Kamyar Kalantar-ZadehGrace H Lee
Nov 28, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emel SenolMustafa Yurtkuran
May 23, 2008·Journal of the American Society of Nephrology : JASN·Ko-Lin KuoDer-Cherng Tarng
Oct 10, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Lillian A RochaMaria Eugênia F Canziani
Oct 17, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Mehdi RambodKamyar Kalantar-Zadeh
Aug 5, 2009·BMC Cardiovascular Disorders·Andy MenkeEliseo Guallar
Nov 12, 2009·Biochemical and Biophysical Research Communications·Takehiro NakaharaMasahiko Kurabayashi
Feb 18, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ellen NevenPatrick C D'Haese
Dec 31, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alejandro Martin-MaloPedro Aljama
May 23, 2014·Frontiers in Pharmacology·Francesca VinchiViktória Jeney

❮ Previous
Next ❯

Citations

Dec 18, 2019·PloS One·Karla Pereira BalbinoHelen Hermana Miranda Hermsdorff
Jun 23, 2016·International Journal of Hematology·Chen-Tung LienMeng-Yi Tsai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.