Serum FGF21 Is Associated with Future Cardiovascular Events in Patients with Coronary Artery Disease

Cardiology
Yun ShenWeiping Jia

Abstract

To investigate whether serum fibroblast growth factor 21 (FGF21) levels can be used to predict the future development of major adverse cardiovascular events (MACEs). This study included 253 patients who received subsequent follow-up, and complete data were collected for 234 patients. Independent predictors of MACEs were identified by using the Cox proportional-hazards regression analysis. The prognostic value of FGF21 levels for MACEs was evaluated by Kaplan-Meier survival analysis. Of 229 patients finally enrolled in the analysis, 27/60 without coronary artery disease (CAD) at baseline experienced a MACE, and 132/169 patients with CAD at baseline experienced a MACE. Among patients with CAD at baseline, serum FGF21 levels were significantly higher in patients with MACEs (p < 0.05) than in patients without MACEs. Kaplan-Meier survival analysis showed patients with a higher serum FGF21 had a significantly lower event-free survival (p = 0.001) than those with a lower level. Further Cox proportional-hazards regression analysis, including the traditional risk factors for cardiovascular disease, showed that serum FGF21 was an independent predictor of MACE occurrence. In patients with CAD at baseline, an elevated serum FGF21 level was...Continue Reading

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Citations

Sep 17, 2019·European Journal of Clinical Investigation·Elena Arellano-OrdenRudolph Schutte
Oct 5, 2020·The Journal of Allergy and Clinical Immunology·Helen HeEmma Guttman-Yassky
Oct 6, 2020·JACC. Basic to Translational Science·Juanjuan Zhao, Liming Pei
Feb 6, 2020·Experimental Gerontology·Kevin F BoreskieTodd A Duhamel
Dec 24, 2020·International Journal of Epidemiology·Whitney L DoKaren N Conneely
Oct 19, 2021·Frontiers in Cardiovascular Medicine·Yuen-Kwun Wong, Hung-Fat Tse

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