Serum Fibroblast Growth Factor 23 (FGF23) in Patients with Rheumatoid Arthritis

Internal Medicine
Hiroe SatoIchiei Narita

Abstract

Objective Rheumatoid arthritis (RA) is a chronic inflammatory disease accompanied by periarticular and systemic osteoporosis. Fibroblast growth factor 23 (FGF23), which is mainly produced by osteocytes, circulates to the kidneys and regulates bone metabolism. We herein assessed serum FGF23 and its relationship to inflammation and osteoporosis in patients with RA. Methods Sixty-one patients with RA were included. Serum concentrations of FGF23 were determined using a sandwich enzyme-linked immunosorbent assay. Results The mean (± standard deviation) serum FGF23 concentration was 34.9±9.2 (range, 21.0-61.0) pg/mL. The serum FGF23 level was significantly and positively correlated with the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, disease activity score-28 based on the ESR (DAS-28 ESR) and DAS-28 CRP (r=0.261, p=0.044, r=0.280, p=0.029, r=0.409, p=0.001 and r=0.421, p=0.001, respectively). The serum matrix metalloproteinase-3 level was also significantly and positively correlated with the serum FGF23 level (r=0.331, p=0.015). Concentrations of type I collagen cross-linked N-telopeptide in the serum was significantly correlated with the serum FGF23 level (r=0.272, p=0.034). Neither the bone mineral densit...Continue Reading

References

May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ShimadaT Yamashita
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Yuji YamazakiSeiji Fukumoto
Jun 7, 2003·American Journal of Physiology. Endocrinology and Metabolism·L Darryl Quarles
Mar 17, 2004·The Journal of Experimental Medicine·Rutger L van BezooijenClemens W G M Löwik
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takashi ShimadaTakeyoshi Yamashita
Nov 9, 2004·The Journal of Biological Chemistry·Hitoshi SaitoNaoshi Fukushima
Dec 8, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Despina SitaraBeate Lanske
Jul 7, 2005·American Journal of Physiology. Renal Physiology·Takashi ShimadaTakeyoshi Yamashita
Jul 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Olga I KolekFayez K Ghishan
Feb 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Shiguang LiuL Darryl Quarles
Jun 25, 1949·Journal of the American Medical Association·O STEINBROCKERR C BATTERMAN
Feb 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hua WangNorihiko Maeda
Aug 9, 2008·PLoS Genetics·Despina SitaraBeate Lanske
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Dec 17, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P ManghatG Hampson
Mar 17, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C J Edwards, E Williams
May 18, 2010·Calcified Tissue International·M J C MoesterR L van Bezooijen
Jul 24, 2010·Annals of the Rheumatic Diseases·Georg SchettJohannes W J Bijlsma
Feb 10, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S A PolyzosE Terpos
Feb 24, 2011·Journal of Bone and Mineral Metabolism·Taichi KitaokaKeiichi Ozono
Aug 30, 2011·Calcified Tissue International·Jesús Delgado-CalleJosé A Riancho
Sep 10, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Tamara IsakovaMyles Wolf
May 5, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Jair Munoz MendozaUNKNOWN Chronic Renal Insufficiency Cohort
Oct 27, 2012·International Journal of Pediatric Endocrinology·Vickie BraithwaiteAnn Prentice
Mar 19, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Myles WolfDavid B Bregman

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Citations

May 18, 2016·Progress in Biophysics and Molecular Biology·Zhengtang QiJianqiang Lu
Jan 29, 2017·Molecular Nutrition & Food Research·Ludmilla BärMichael Föller
Sep 2, 2016·American Journal of Physiology. Renal Physiology·Valentin DavidJodie L Babitt
Sep 15, 2019·Nature Reviews. Nephrology·Daniel Edmonston, Myles Wolf
Jul 28, 2020·International Journal of Molecular Sciences·Hideki KitauraItaru Mizoguchi
May 19, 2016·Current Opinion in Nephrology and Hypertension·Connor Francis, Valentin David
Mar 28, 2019·Current Osteoporosis Reports·Miao ZhouJanak L Pathak
Mar 11, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Quiana McKnightJackie A Fretz
Jun 15, 2019·FEBS Letters·Ludmilla BärMichael Föller
Apr 12, 2019·Frontiers in Physiology·Annelies J van VurenEduard J van Beers
Jul 1, 2020·Terapevticheskiĭ arkhiv·A A AbramkinE L Nasonov
Jan 22, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Arezoo DaryadelIsabel Rubio-Aliaga
Feb 7, 2021·BMC Musculoskeletal Disorders·Katharina Kerschan-SchindlPeter Pietschmann
Mar 24, 2021·Néphrologie & thérapeutique·Assétou Diarrassouba
Jun 1, 2021·Disease Markers·Anna KurpasMarzenna Zielińska
Jul 24, 2021·CEN Case Reports·Shunsuke ShimazakiMasanori Minagawa
Nov 4, 2021·Molecular and Cellular Biochemistry·Jana Alber, Michael Föller
Nov 11, 2021·Current Osteoporosis Reports·Petra Simic, Jodie L Babitt

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