Serum Folate Correlates with Severity of Guillain-Barré Syndrome and Predicts Disease Progression

BioMed Research International
Yang GaoJiachun Feng

Abstract

The aim of this study was to determine the associations between serum folate level and the clinical course and severity of Guillain-Barré syndrome (GBS). We retrospectively enrolled 112 pairs of GBS patients and age- and sex-matched healthy controls with measured serum folate levels. On admission, 21 (18.9%) GBS patients had folate deficiency, of which only two were female patients. Patients with normal folate levels had a shorter disease progression than those with folate deficiency (median progression duration: 6 versus 13 days, p < 0.001). Serum folate levels on admission were correlated with progression duration and Medical Research Council (MRC) sum score in the upper limbs at nadir (r = -0.261, p = 0.005; r = -0.208, p = 0.03) but not with the duration of hospital stay or GBS disability score (p > 0.05). Logistic regression analysis revealed that normal folate levels on admission were an independent predictor of faster GBS progression, along with younger age, intact deep sensation, and a lower MRC sum score on admission. These results show that serum folate levels are correlated with the progression duration and severity of GBS. Further studies are required to confirm the potential of folate level as a biomarker for GBS p...Continue Reading

References

Mar 1, 1975·The American Journal of Clinical Nutrition·R L GrossW Hift
Jan 1, 1972·Transactions of the Royal Society of Tropical Medicine and Hygiene·P J HamiltonF Lothe
Jan 1, 1982·The American Journal of Clinical Nutrition·B J Brabin
Apr 8, 2006·The American Journal of Clinical Nutrition·Parul ChristianKeith P West
Jun 7, 2007·JAMA : the Journal of the American Medical Association·Bernard F ColeUNKNOWN Polyp Prevention Study Group
Nov 21, 2007·Gastroenterology·Richard F A LoganUNKNOWN ukCAP Trial Group
Nov 6, 2008·JAMA : the Journal of the American Medical Association·Shumin M ZhangJoann E Manson
Jun 18, 2009·Critical Care Medicine·Julian StraussTarek Sharshar
Nov 19, 2009·JAMA : the Journal of the American Medical Association·Marta EbbingStein Emil Vollset
Jun 15, 2012·The New England Journal of Medicine·Nobuhiro Yuki, Hans-Peter Hartung
Oct 29, 2013·Brain : a Journal of Neurology·Christiaan FokkeBart Casper Jacobs
Feb 11, 2015·Neurology·Haruki KoikeGen Sobue
Mar 8, 2016·Lancet·Hugh J WillisonPieter A van Doorn
Mar 15, 2016·The International Journal of Neuroscience·Jussi O T SipiläMerja Soilu-Hänninen
Oct 11, 2017·Drug and Alcohol Dependence·Arantza SanvisensRobert Muga

❮ Previous
Next ❯

Citations

Mar 7, 2020·Journal of Neurology·Pei ShangHong-Liang Zhang
May 18, 2021·Frontiers in Pharmacology·Pei ShangHong-Liang Zhang

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
SPSS Statistics
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.