Serum free circulating DNA is a useful biomarker to distinguish benign versus malignant prostate disease

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Edna GordianRakesh Singal

Abstract

Free circulating DNA (fcDNA) has been shown to be elevated in serum of prostate cancer patients compared with benign controls. However, studies evaluating the role of fcDNA as a biomarker in a "representative" patient group who have undergone prostate cancer screening are lacking. Our study examined the use of serum fcDNA levels as a biomarker of prostate cancer in such a setting. The study included 252 men, with prostate-specific antigen (PSA) levels >4 ng/mL and/or abnormal digital rectal exam. fcDNA levels in serum before prostate biopsy were quantitated by real-time PCR amplification of the glutathione S-transferase, pi, gene. Patients with PSA < or = 10 ng/mL with fcDNA > 180 ng/mL were at increased risk for prostate cancer compared with those with fcDNA < or =180 ng/mL (odds ratio, 4.27; 95% confidence interval, 2.05-8.88; P < 0.001; area under the curve, 0.742). The multivariate model including age, race, PSA, fcDNA, and interaction between fcDNA and PSA yielded a high negative predictive value of 93.1% and increased specificity of 33.1% compared with negative predictive value of 73.3% and specificity of 6.7% in the model excluding fcDNA. Our results indicate that fcDNA may improve the specificity of prostate cancer scre...Continue Reading

References

Feb 24, 2001·Annals of the New York Academy of Sciences·P Davies
May 29, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tsu-Lan WuJames T Wu
Sep 26, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gabriella SozziUgo Pastorino
May 28, 2004·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Jul 15, 2004·Annals of the New York Academy of Sciences·Bret TabackDave S B Hoon
Jul 15, 2004·Annals of the New York Academy of Sciences·Darrell AllenR Swaminathan
Oct 20, 2004·Oncology Research·Eirini PapadopoulouGeorgios Nasioulas
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jane L BoddyJim S Wainscoat
Dec 22, 2005·Journal of the National Cancer Institute·Gabriella SozziUgo Pastorino
Dec 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emanuela FlaminiDino Amadori
Sep 4, 2007·International Journal of Cancer. Journal International Du Cancer·Jörg EllingerAlexander von Ruecker
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrick J BastianWilliam G Nelson
Apr 23, 2008·American Journal of Clinical Pathology·Annalisa AltimariMichelangelo Fiorentino
Oct 8, 2008·Annals of the New York Academy of Sciences·Anna V CherepanovaPavel P Laktionov
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Heidi SchwarzenbachKlaus Pantel
Mar 14, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiaoyan XuePenella J Woll
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

❮ Previous
Next ❯

Citations

Nov 26, 2011·Cancer Causes & Control : CCC·Ray S Lin, Sylvia K Plevritis
Jul 23, 2011·Pathology Oncology Research : POR·Zhaohui HuangYanjun Zeng
Dec 8, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hideo TanakaDaisuke Aoki
Jul 9, 2013·Journal of Clinical Pathology·Benisio Ferreira da Silva FilhoLuiz Antonio Ferreira Silva
Feb 13, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jin WangSubrata Sen
Jun 1, 2014·Critical Reviews in Clinical Laboratory Sciences·Bernhard RallaKlaus Jung
Feb 9, 2016·Diagnostics·Virginie Vlaeminck-Guillem
Apr 17, 2012·Expert Opinion on Biological Therapy·Elena Y RykovaPavel P Laktionov
Nov 29, 2015·The Urologic Clinics of North America·Jeffrey J TosoianChristian P Pavlovich
Mar 20, 2013·BioMed Research International·Valentina CasadioWainer Zoli
Jun 3, 2016·Expert Review of Molecular Diagnostics·Wendy Shuwen He, Karen Suzanne Bishop
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Frank PeinemannStefan Sauerland
Aug 18, 2020·Critical Reviews in Clinical Laboratory Sciences·Giovanni PontiTomris Ozben
Aug 14, 2019·Cells·Dada Oluwaseyi TemilolaLuiz Fernando Zerbini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.