Serum free thyroxine concentrations in normal euthyroid subjects and ones with high serum thyroxine binding globulin concentration

Clinica Chimica Acta; International Journal of Clinical Chemistry
D B RamsdenR Hoffenberg

Abstract

Serum free thyroxine (fT4) was assayed by a commercial fT4 method in 30 normal euthyroid subjects, 19 pregnant females, 13 euthyroid subjects with high thyroxine binding globulin (TBG) and three with low or undetectable serum TBG concentration. In a number of these fT4 was also calculated on the basis of the application of the law of mass action to the binding situation. In states in which TBG was altered for congenital reasons both the experimentally determined and calculated fT4 were not significantly different from their respective means in the normal euthyroid population. Pregnant females had both lower experimental and theoretical free T4 concentrations. It is inferred from these data that TBG concentration per se is without effect on serum fT4 concentration.

References

Feb 19, 1977·British Medical Journal·W A BurrR Hoffenberg
Oct 1, 1977·Clinical Endocrinology·H P Princé, D B Ramsden
Nov 11, 1978·British Medical Journal·R T Cooke
Dec 2, 1978·British Medical Journal·J How, P D Bewsher
Apr 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J N RameyR K Donabedian
Mar 1, 1976·The Journal of Clinical Endocrinology and Metabolism·H UchimuraS H Ingbar
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
May 1, 1969·The Journal of Clinical Endocrinology and Metabolism·B U MusaJ T Dowling
Dec 1, 1967·The Journal of Clinical Endocrinology and Metabolism·J T DowlingJ T Nicoloff
Jul 1, 1960·The Journal of Clinical Investigation·J T DOWLINGS H INGBAR
May 1, 1962·The Journal of Clinical Investigation·K STERLING, A HEGEDUS

❮ Previous
Next ❯

Citations

Nov 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·S M GowG J Beckett
Aug 1, 1994·Acta Paediatrica Japonica; Overseas Edition·A NakaiM Sudo
Jan 1, 1987·Critical Reviews in Clinical Laboratory Sciences·G H White
Jul 2, 1984·Klinische Wochenschrift·A PassathP Ollinger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.