Serum from women with preeclampsia partially corrects the abnormal in vitro prostacyclin secretion of preeclamptic villous cytotrophoblasts but not that of prostaglandin E2 or endothelin-1

American Journal of Obstetrics and Gynecology
Z Q DingE D Gallery

Abstract

This study was conducted (1) to determine in vitro placental villous cytotrophoblast secretion of prostacyclin, prostaglandin E2, and endothelin-1, (2) to examine the effect of serum from normal and preeclamptic women on secretion of these vasoactive substances, and (3) to determine whether responses to these sera by cytotrophoblasts from preeclamptic pregnancies are different from those of normal pregnancies. Cytotrophoblasts isolated from human placentas collected at cesarean section from normal and preeclamptic women were incubated for 20 hours in 20% (vol/vol) sera from preeclamptic or gestational age-matched normal pregnant women. Levels of prostacyclin (measured as 6-keto-prostaglandin F1alpha), prostaglandin E2, and endothelin-1 were measured in cytotrophoblast supernatants. In normal pregnancy sera preeclamptic cytotrophoblasts secreted significantly lower amounts of prostacyclin and prostaglandin E2 but higher amounts of endothelin-1 than did normal cytotrophoblasts. In preeclamptic sera the abnormality of prostacyclin secretion by preeclamptic cytotrophoblasts was partially corrected, but there was no effect on prostaglandin E2 or endothelin-1 secretion. Preeclamptic sera had no effect on secretion by normal cytotroph...Continue Reading

References

May 17, 1979·The New England Journal of Medicine·S Moncada, J R Vane
Mar 1, 1992·American Journal of Obstetrics and Gynecology·B A ClarkF H Epstein
Mar 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D W BranchM D Mitchell
Sep 1, 1991·American Journal of Obstetrics and Gynecology·A NovaM D Mitchell
Mar 31, 1990·Lancet·D J FitzgeraldG A FitzGerald
Sep 1, 1988·American Journal of Obstetrics and Gynecology·B J TrudingerA Connelly
Mar 1, 1987·American Journal of Obstetrics and Gynecology·P R BennettM G Elder
Jan 1, 1985·American Journal of Obstetrics and Gynecology·S W WalshN H Allen
Jun 1, 1985·American Journal of Obstetrics and Gynecology·S W Walsh
Oct 1, 1984·British Journal of Obstetrics and Gynaecology·A R Fuchs, F Fuchs
Jun 1, 1995·The Journal of Clinical Endocrinology and Metabolism·S W Walsh, Y Wang
Jan 1, 1996·European Journal of Clinical Investigation·M CervarG Desoye

❮ Previous
Next ❯

Citations

Jan 15, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S ZiaeiM Lamyian
Jun 26, 2007·Journal of Clinical Periodontology·Varol CanakciAyşe Erturk
Nov 19, 2003·American Journal of Therapeutics·Freddy ContrerasManuel Velasco
Jun 28, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·E D GalleryC Jackson
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Nonna MakkonenPertti Kirkinen
Apr 15, 2006·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Saeideh ZiaeiAnoshirvan Kazemnejad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.