PMID: 9186269May 1, 1997Paper

Serum FSH levels in women with polycystic ovary syndrome during ovulation induction using down-regulation and urofollitropin

European Journal of Endocrinology
M FridströmT Hillensjö

Abstract

To evaluate retrospectively the use of serum FSH levels and to correlate them with follicular growth in a clinical ovulation induction program. Twenty women with infertility due to anovulation associated with polycystic ovary syndrome (PCOS) were studied. The patients were down-regulated with a long GnRH agonist protocol and stimulated with purified urofollitropin, using a low-dose step-up regimen. Repeated serum samples were drawn and transvaginal ultrasound scans were-performed. During the exogenous FSH therapy serum FSH levels resulting in continuous follicular growth were analyzed, as well as the rates of ovulation, pregnancy, cancellation and conversion to in vitro fertilization (JVF). Thirty-two out of fifty treatment cycles led to ovulation, resulting in five term pregnancies. Eight cycles were converted to IVF/embryo transfer due to multiple follicular growth. They resulted in two pregnancies. Ten cycles were cancelled because of impaired follicular growth. The serum FSH levels (median 6 IU/I) resulting in continuous growth of the follicles were relatively stable within patients (variation 15%) but varied considerably between patients (45%). The relationship between FSH dose and serum level was different for lean and ob...Continue Reading

Citations

Apr 28, 2009·Current Opinion in Obstetrics & Gynecology·Cemal Tamer Erel, Levent Mehmet Senturk
Apr 17, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Christopher J Brewer, Adam H Balen
Mar 23, 2011·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M T OzgunY Sahin
Jun 23, 2006·Reproductive Biomedicine Online·José BellverCarlos Simón
Jan 19, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Herve DechaudBernard Hedon
Jul 23, 2009·The Journal of Family Planning and Reproductive Health Care·Scott Wilkes, Alison Murdoch

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